2007
DOI: 10.1016/j.brainres.2007.01.010
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Metabotropic glutamate receptor/phospholipase C system in female rat heart

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Cited by 9 publications
(11 citation statements)
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“…A similar study showed positive staining for mGluR1 and mGluR5 in both atrial and ventricular human cardiomyocytes (Gill et al, 2007). Another study has reported the presence of mGluR1 and mGluR5 in whole rat heart homogenates, as well as demonstrating a functional coupling of these receptors to phospholipase C (Iglesias et al, 2007). Although a recent study did not detect any metabotropic glutamate receptor in mouse heart (Regard et al, 2008), we and Zhu et al (1999) found a high expression of mGluR1b in mouse heart.…”
Section: Discussioncontrasting
confidence: 58%
See 1 more Smart Citation
“…A similar study showed positive staining for mGluR1 and mGluR5 in both atrial and ventricular human cardiomyocytes (Gill et al, 2007). Another study has reported the presence of mGluR1 and mGluR5 in whole rat heart homogenates, as well as demonstrating a functional coupling of these receptors to phospholipase C (Iglesias et al, 2007). Although a recent study did not detect any metabotropic glutamate receptor in mouse heart (Regard et al, 2008), we and Zhu et al (1999) found a high expression of mGluR1b in mouse heart.…”
Section: Discussioncontrasting
confidence: 58%
“…mGluR1 was the only metabotropic glutamate receptor transcript in our mouse repertoire as opposed to the rat heart (Iglesias et al, 2007). We were unable to detect any specific band corresponding to the mGluR1 protein in the mouse heart (data not shown).…”
Section: Gpcr Repertoire In Mouse Heart Chambers 1111mentioning
confidence: 80%
“…It is noteworthy that maternal intake of caffeine during rat gestation causes downregulation of mGlu1 protein level in the fetus heart and a loss of responsivity to several mGlu receptor agonists in membrane preparations isolated from the heart of the fetus (Iglesias et al, 2006). Pregnancy itself seems not to affect mGlu-associated PLC pathway in that L-glutamate-or quisqualate-mediated PLC activity was not modified by the pregnant or nonpregnant state (Iglesias et al, 2007).…”
Section: Other Tissues Expressing Metabotropic Glutamate Receptorsmentioning
confidence: 96%
“…It has been shown that acidic derivatives of Hcy, like homocysteic acid (HcyA), activate mGluRs in neuronal and non-neuronal tissues, initiate G-protein mediated signalling and cause an increase in [Ca 2+ ] i [21]. mGluRs have also been found in mammalian heart [22]. iGluRs are present in various mammalian tissues as well [17,19,23].…”
Section: Nmda-r and Ca 2+mentioning
confidence: 99%