Metacarpal growth and systemic markers of bone metabolism in the ovine fetus

Abstract

Bone metabolism was assessed in 56 Ile de Francex(RomanovxLimousine) fetal lambs killed between Day 80 and Day 145 of gestation. In each fetus, the length, width and weight, as well as the calcium and phosphorus content of the left diaphyseal metacarpal bone were measured. Plasma alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) activities, bone ALP (B-ALP), osteocalcin (OC) and insulin-like growth factor-I (IGF-I) were assayed in these fetuses and in six newborn lambs from birth until one month after birth. Fetal growth is characterized by an increase in bodyweight, bone size and bone mineral content from Day 80 to Day 132 of gestation. These parameters did not significantly vary until birth. Plasma concentrations of IGF-1, OC and B-ALP increased from Day 80 to Day 132. Between Day 132 and birth, plasma IGF-I and B-ALP concentrations did not significantly vary, whereas plasma OC concentration decreased, confirming the usefulness of OC as a marker of osteoblastic activity and bone formation in the ovine species. The increase in plasma IGF-I, B-ALP and OC concentrations observed during the first two weeks of postnatal life indicate an intense skeletal growth in these animals, which was confirmed by the bodyweight growth curve.

Uma Análise Da Oferta No Varejo Brasileiro De Produtos Oriundos De Processo De Produção Com Bem-Estar Animal

“…It was reported that goats showed a more accelerated bone remodelling that sheep, which was demonstrated by ICTP, CTx (LIESEGANG et al, 2003), BALP (LIESEGANG et al, 2003;SOUSA et al, 2014a), and OC determinations in various studies (PASTOUREAU et al, 1991;LIESEGANG et al, 2003). Collignon et al (1996) demonstrated that bone growth since the fetal stage produces alterations in serum OC and BALP, confirming the usefulness of these markers in bone formation and growth. Scott et al (1997) reported that OC, BALP, DPD, and PYD may be useful for detection of changes in bone growth caused by deficient diets, and Wan Zahari et al (1994) reported that high phosphorus diets resulted in increased bone resorption (increased TRAP) in lambs.…”

Perfil Do Consumidor De Carne Do Bairro De Dois Irmãos Na Cidade Do Recife- Pernambuco

“…It was reported that goats showed a more accelerated bone remodelling that sheep, which was demonstrated by ICTP, CTx (LIESEGANG et al, 2003), BALP (LIESEGANG et al, 2003;SOUSA et al, 2014a), and OC determinations in various studies (PASTOUREAU et al, 1991;LIESEGANG et al, 2003). Collignon et al (1996) demonstrated that bone growth since the fetal stage produces alterations in serum OC and BALP, confirming the usefulness of these markers in bone formation and growth. Scott et al (1997) reported that OC, BALP, DPD, and PYD may be useful for detection of changes in bone growth caused by deficient diets, and Wan Zahari et al (1994) reported that high phosphorus diets resulted in increased bone resorption (increased TRAP) in lambs.…”

Combinação Do Exercício Fisico E Ração Hipocalorica Para Tratar a Obesidade De Cães Guias

“…It was reported that goats showed a more accelerated bone remodelling that sheep, which was demonstrated by ICTP, CTx (LIESEGANG et al, 2003), BALP (LIESEGANG et al, 2003;SOUSA et al, 2014a), and OC determinations in various studies (PASTOUREAU et al, 1991;LIESEGANG et al, 2003). Collignon et al (1996) demonstrated that bone growth since the fetal stage produces alterations in serum OC and BALP, confirming the usefulness of these markers in bone formation and growth. Scott et al (1997) reported that OC, BALP, DPD, and PYD may be useful for detection of changes in bone growth caused by deficient diets, and Wan Zahari et al (1994) reported that high phosphorus diets resulted in increased bone resorption (increased TRAP) in lambs.…”