Metacarpophalangeal Joint Impairment in Hand Osteoarthritis and Its Association With Mechanical Factors: Results From the Digital Cohort Osteoarthritis Design Hand Osteoarthritis Cohort

Abstract

Objective: To determine the prevalence, distribution and characteristics associated with radiographic metacarpophalangeal (MCP) osteoarthritis (OA).Methods: This is a cross-sectional study of baseline data from the DIGItal Cohort Osteoarthritis Design, a French monocentric cohort including patients with symptomatic hand OA (HOA). We evaluated the prevalence of radiographic MCP OA defined as ≥2 MCP joints with a Kellgren and Lawrence score ≥2. We compared the prevalence of MCP OA in the dominant and non-dominant hands. Associations between radiographic MCP OA and patient characteristics were studied using univariable and multivariable logistic regression.Results: Radiographic MCP OA was present in 138 of the 425 patients (32.5%) but was not severe. Patients with MCP OA had a mean age of 69.2±6.9 years, a BMI of 25±4.2 kg/m 2 , and 86.2% were women. MCP OA was more frequent in the dominant hand and predominated at the 1st and 2nd MCP joints. In the multivariable analysis, MCP OA was associated with older age (OR 1.05, 95%CI [1.01,1.10] for each year), manual occupation (OR 3.74, 95%CI [1.21,11.54]), scaphotrapezial OA (OR 2.18, 95%CI [1.27,3.72]), and a high number of proximal interphalangeal joints with radiographic OA. MCP OA was not associated with metabolic syndrome or HOA symptoms. Conclusion:In this cross-sectional study using a hospital-based HOA cohort, radiographic MCP OA was frequent and associated with structural HOA features rather than with symptom severity. Our results suggest that the involvement of MCP joints in HOA is predominantly related to mechanical rather than systemic factors in this population.

Using Sensorized Gloves and Dimensional Reduction for Hand Function Assessment of Patients with Osteoarthritis

“…These five synergies are coherent with previous studies: the first two PCs referring to finger MCP and PIP arching [ 29 , 42 , 44 , 45 ] and higher order synergies referring to fine manipulation coordination [ 35 ]. Patient synergies are similar to the healthy ones for the finger’s arch and hand closure, although the latter explains less variance, which is probably due to MCP compromise in HOA patients [ 46 ]. However, patients’ higher order synergies differ from those of healthy subjects.…”