Metachronous bilateral soft tissue sarcoma of the extremities

Daigeler, Adrien; Lehnhardt, Marcus; Sebastian, Anita; Belyaev, Orlin; Steinstraesser, Lars; Steinau, Hans-Ulrich; Kühnen, C.

doi:10.1007/s00423-006-0145-2

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…It was proposed that these patients may have a genetic predisposition to malignant disease, or they may have been exposed to carcinogens [5]. Reports of multiple primary sarcomas unassociated with a predisposing syndrome (e. g. neurofi bromatosis, familial adenomatous poly posis, retinoblastoma, or Li-Fraumeni syndrome) are rather anecdotal, particularly those referring to tumors localized in soft tissues of the extremities [6,11,12]. Daigeler et al [6] presented an interesting notion of the subsequent occurrence of a STS being an atypical manifestation of metastatic disease.…”

Section: Resultsmentioning

confidence: 99%

“…Reports of multiple primary sarcomas unassociated with a predisposing syndrome (e. g. neurofi bromatosis, familial adenomatous poly posis, retinoblastoma, or Li-Fraumeni syndrome) are rather anecdotal, particularly those referring to tumors localized in soft tissues of the extremities [6,11,12]. Daigeler et al [6] presented an interesting notion of the subsequent occurrence of a STS being an atypical manifestation of metastatic disease. With respect to the diff erentiation between a true synchronous, independently developed soft tissue sarcoma and its metastases, this might seem plausible,…”

Section: Resultsmentioning

confidence: 99%

“…As for the association of STS with other malignancies, this was recorded in patients with genetic disorders such as neurofibromatosis, familial adenomatous polyposis, retinoblastoma, and Li-Fraumeni syndrome. Moreover, several studies have suggested that patients with STS are at an increased risk of developing a second malignancy, notably breast and kidney cancer, regardeless of any underlying genetic disorder present [5][6][7]. Most cases of STS in adult patients (94%) are not significantly related to common risk factors such as radiation, genetic disease, and chronic lymphedema [1].…”

Section: Backgroundsmentioning

confidence: 99%

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Multiple Metachronous Malignant Fibrous Histiocytomas of the Upper Limbs – a Case Report

Šćepanović¹,

Masarykova

Pobijakova

et al. 2014

Klin Onkol

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Background: Soft-tissue sarcomas are rare tumors with the incidence of multiple metachronous or synchronous lesions in the extremities being even more uncommon. In eff ort to preserve the function of upper extremities, limb-salvage surgery became the treatment of choice for soft-tis sue sarcomas. Subsequent adjuvant chemotherapy, as well as radiotherapy, is believed to decrease local recurrence rates, however, their eff ect on overall survival remains unclear. Case: We report herein a case of symmetrical bilateral metachronous malignant fi brous histiocytomas of the shoulder. A 19-year-old patient presented with stiff ness and pain in the right shoulder. The same symptoms developed 1.5 years later in the other shoulder. The culprit tumors are reported metachronous with regard to the succession in the onset of symptoms. Wide tumor resection was performed in both shoulders, and postoperative radiotherapy was then conducted. Chemotherapy was not indicated after the fi rst surgery; whereas, in the second case it was the patient who refused the recommended adjuvant chemotherapy. Conclusion: The phenomenon of either metachronous or synchronous incidence of multiple soft tissue sarcomas is very rare and systematic reporting of every new case in the literature could contribute to further knowledge of tumor's unique behavior.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Backgroundsmentioning

confidence: 99%

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Multiple Metachronous Malignant Fibrous Histiocytomas of the Upper Limbs – a Case Report

Šćepanović¹,

Masarykova

Pobijakova

et al. 2014

Klin Onkol

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“…The reason behind this occurrence remains unclear regarding the etiology of the bilateralism. Possible etiologic factors for the development of second lesions include irradiation effects, exposure to other carcinogenic agents, and genetic predisposition (Recklinghausen neurofibromatosis and chronic lymphedema are possible contributing factors) [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Metachronous Bilateral Extremity Soft Tissue Sarcomas

et al. 2016

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Case seriesPatient: Male, 44 • Male, 58Final Diagnosis: Soft tissue sarcomasSymptoms: Discomfort • swellingMedication: —Clinical Procedure: Image guided biopsy • metastatic work up • neoadjuvant radiotherapy • radical resectionSpecialty: SurgeryObjective:Rare diseaseBackground:Soft tissue sarcomas (STS) account for approximately 1% of adult malignancies, with 50 to 60% occurring in the extremities. Liposarcoma is the most common type of STS and represent about 20% of total adult sarcomas. There are rare syndromes associated with increased risk of developing STS. Further, chemical compounds such as chlorinated phenols and a few chemotherapeutic drugs have been linked to STS, along with ionizing radiation. Nevertheless, the etiology is uncertain for most of these lesions.Case Report:This report details 2 cases of metachronous bilateral STS of the lower extremities. The first of these presented as a local recurrence of a previously resected right thigh liposarcoma and a new liposarcoma in the left thigh. As mentioned above, among the different subtypes of STS, liposarcoma has the highest tendency for multifocality. The second patient had multifocal metachronous leiomyosarcoma with lung metastases occurring simultaneously with the second presentation. Leiomyosarcoma is another subtype reported to present with multi-focal disease.Conclusions:Despite the rarity of bilateral lesions, their occurrence should not be overlooked in the initial diagnosis and follow-up of the initially detected tumor. Early detection can affect patient survival because their presence predicts unfavorable outcomes.

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“…Also, although other soft tissue sarcomas have been reported as metachronous, there no reports of metachronous LMS but there are few series of multicentric (synchronous). A genetic predisposition for dedifferentiation of the tissues or congenital and acquired immunodeficiency may promote the clustering of sarcomas in one person [24][25][26] . In view of limited literature on this topic and our unique presentation, both the scapular region mass and renal mass could represent blood borne metastasis or could be a part of the metachronous tumor.…”

Section: Discussionmentioning

confidence: 99%

Successful management of renal leiomyosarcoma using radiofrequency ablation: Case report and brief review of literature

Bhatia

Parekh²,

Pereira

et al. 2014

JST

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Metachronous Leiomyosarcoma are a rare entity in literature. Renal Leiomyosarcoma (LMS) have an aggressive biological behavior with poor prognosis despite surgery. We report the use of a minimally invasive percutaneous Radiofrequency Ablation (RFA) in management of this tumor.We report a case of 72 year old woman with a history of the inferior vena cava (IVC) LMS surgically treated 7 year ago and with metachronous/delayed presentation of subcutaneous LMS in scapular region and renal LMS, the later successfully treated with RFA. RFA seems to be an alternative procedure for patients with extended disease and comorbidities.

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Metachronous bilateral soft tissue sarcoma of the extremities

Abstract: The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome.

Cited by 7 publications

References 14 publications

Multiple Metachronous Malignant Fibrous Histiocytomas of the Upper Limbs – a Case Report

Multiple Metachronous Malignant Fibrous Histiocytomas of the Upper Limbs – a Case Report

Metachronous Bilateral Extremity Soft Tissue Sarcomas

Successful management of renal leiomyosarcoma using radiofrequency ablation: Case report and brief review of literature

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