Metachronous bladder metastases of a type 2 papillary renal cell carcinoma: a case report and review of the literature

Gajasinghe, D. G. V. D. Seneth; Nazeer, Ishra; Maddumage, H.; Perera, Chrysantha; Abeygunasekera, Anuruddha M

doi:10.1186/s12957-016-0986-2

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…In the earliest case reported by Raviv et al ( 12 ), the patient received no adjuvant treatment after TURBT but conservative surveillance and was alive and free of disease six years after initial TURBT. In the study by Gajasinghe et al ( 10 ), the patient did not receive any adjuvant treatment until bladder metastasis was detected. Then, although she received interferon-alpha injections thrice a week, lung metastasis was subsequently developed.…”

Section: Discussionmentioning

confidence: 99%

“…The most common organs of metastasis include the lungs, bones, lymph nodes and skin (9), while the bladder only accounts for approximately 2% of RCC metastases (7). Bladder metastasis of type-2 PRCC is rare, and only four cases have been reported (10)(11)(12)(13). In the earliest case reported by Raviv et al (12), the patient received no adjuvant treatment after TURBT but conservative surveillance and was alive and free of disease six years after initial TURBT.…”

Section: Discussionmentioning

confidence: 99%

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Bladder metastasis from type 2 papillary renal cell carcinoma: A case report

et al. 2023

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Renal cell carcinoma (RCC) is a common urinary tumor that may be pathologically divided into different subtypes: clear cell RCC, papillary RCC (PRCC) and chromophobe RCC. The most common organs of RCC metastasis are the lung, liver and bones, while bladder metastasis is rare. The treatment for PRCC metastasis is also a problem due to limited clinical data. Therefore, every single case of PRCC metastasis may significantly contribute to establishing a standard treatment protocol. The present study reported on a patient who suffered from repetitive bladder PRCC metastasis with 1.5 years of follow-up. A 54-year-old male patient was diagnosed with left renal pelvic carcinoma in March 2020 and underwent a laparoscopic radical nephroureterectomy of the left kidney. The postoperative histological examination revealed that the tumor was consistent with a type 2 PRCC. Bladder metastasis was discovered three months after the surgery and transurethral resection of the bladder tumor (TURBT) was performed to eliminate the tumor in the bladder. Only three months after the initial TURBT, bladder metastasis was detected again, combined with lung metastasis. The patient refused to undergo radical cystectomy. Therefore, a second TURBT was arranged and targeted drugs were administered. However, both bladder and lung metastases were insensitive to the treatment strategy applied, although immunotherapy was subsequently added. The patient died in October 2021 due to respiratory failure and cachexia. The report aims to provide the whole treatment progress and lessons learned from this case, which is relatively rare.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bladder metastasis from type 2 papillary renal cell carcinoma: A case report

et al. 2023

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Rare metastasis of renal cell carcinoma to the bladder with a new hypothesis and literature review: Case report

Manav,

Şahin

2024

Preprint

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Background Metastatic renal cell carcinoma (RCC) to the bladder is extremely rare. A total of 1.6% of the patients were found via autopsy reports. Case presentation: A 44-year-old male patient underwent left nephroureterectomy + ureteral cuff resection because of a left endophytic renal mass and suspected upper tract urothelial carcinoma. Pathology revealed papillary renal cell carcinoma (RCC). In the patient with hematuria, a 16x11 mm mass was detected on the left sidewall of the bladder 2 years after nephrectomy. Papillary RCC was detected after complete transurethral resection of the bladder tumor. When we evaluated the literature, we developed the hypothesis that the periureteral venous plexus pathway is involved in metastasis. Left iliac lymph node metastasis was detected via postoperative positron emission tomography (PET-CT). After 6 months of sunitinib treatment, the metastatic lymphadenopathy was found to regress on PET-CT. Conclusion Solitary resectable intravesical metastatic RCC is a good prognostic factor. Late-onset systemic metastasis may be observed and should be considered during follow-up. If necessary, PET-CT scanning should be performed, and the patient can be treated with sunitinib.

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Metachronous bladder metastases of a type 2 papillary renal cell carcinoma: a case report and review of the literature

Cited by 2 publications

References 17 publications

Bladder metastasis from type 2 papillary renal cell carcinoma: A case report

Bladder metastasis from type 2 papillary renal cell carcinoma: A case report

Rare metastasis of renal cell carcinoma to the bladder with a new hypothesis and literature review: Case report

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