Metachronous Coexistence of Laryngeal Pseudolymphoma and Squamous Cell Carcinoma

Ferlito, Alfio; Doglioni, Claudio; Bontempini, L; Arrigoni, Arrigo

doi:10.1159/000275710

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…The stimulated squamous epithelium may then have led to squamous cell carcinoma. The present case suggests that MALT-type lymphoma of the larynx can coexist with squamous cell carcinoma, as previously reported by Ferlito et al (1984). Although pseudolymphoma was previously considered as benign, it is now classified as MALT-type lymphoma which is a low-grade malignancy.…”

Section: Discussionsupporting

confidence: 83%

“…MALT-type lymphoma was first described by Isaacson and Wright (1983) in the gastrointestinal tract and subsequently reported by Diebold et al (1990) in the larynx. The term 'pseudolymphoma' had previously been used by several authors (Salkeld, 1955;Climie et al, 1964;Mabry, 1967;Al-Saleem et al, 1970;Pellettiere et al, 1980;Ferlito et al, 1984) for such tumours, until they were classified as MALT-type lymphomas (Isaacson and Spencer, 1987;Diebold et al, 1990). This type of lymphoma is characterized by the proliferation of centrocytelike and lymphoplasmacytic cells, and the presence of lymphoepithelial lesions and germinal centres Isaacson and Spencer, 1987;Isaacson, 1992).…”

Section: Discussionmentioning

confidence: 99%

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Coexistence of MALT-type lymphoma and squamous cell carcinoma of the larynx

et al. 1994

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A 66-year-old Japanese man was diagnosed as having a MALT-type lymphoma by histopathological examination. The lesion involved the vocal folds bilaterally, occupying the larynx and extending beyond it, as shown by computed tomography (CT). A course of radiation therapy with moderate doses was given. Six months later, a squamous cell carcinoma was found in the larynx and total laryngectomy was then performed. The patient remained well, without recurrence, 46 months after the operation, thus, MALT-type lymphoma may coexist with a squamous cell carcinoma of the larynx.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Coexistence of MALT-type lymphoma and squamous cell carcinoma of the larynx

et al. 1994

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“…A similar case was reported in 1994 by Nageris et al, 25 who described a rare case of f ibrosarcoma of the vocal cord extending into and obliterating the paralaryngeal space, following radiotherapy for a glottic squamous cell carcinoma. In 1984, Ferlito et al 19 reported a metachronous coexistence of laryn- geal mucosa-associated lymphoid tissue (MALT) lymphoma (of a low grade of malignancy) and squamous cell carcinoma, with the term "pseudolympho- An apparent association of epithelial and mesenchymal neoplasms of the larynx is not always confirmed on closer scrutiny; for example, it is important to distinguish solitary tumors manifesting bidirectional or multidirectional differentiation from true synchronous primary cancers of the larynx originating from 2 discrete, different malignant clones. The 3 cases described in the literature of squamous cell carcinoma and rhabdomyosarcoma of the larynx were all synchronous.…”

mentioning

confidence: 99%

“…Note diffuse lymphocytic infiltrate and intact squamous epithelium. (Reprinted with permission 19 ). ma" used to indicate the MALT lymphoma (Figs 1-5 19 ).…”

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confidence: 99%

Synchronous and Metachronous Multiple Primary Laryngeal Malignancies

Ferlito¹,

Rinaldo²,

Ko³

et al. 1998

Ann Otol Rhinol Laryngol

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The article reviews the literature on synchronous and metachronous multiple primary malignant laryngeal tumors of the same phenotype, of different phenotypes, and of different histogenesis.The development of a second or even third primary cancer involving the same system is not uncommon. For instance, the association of cancer of the larynx with lung cancer has been increasing and can be explained by the presence of common pathogenetic factors acting in the respiratory system.Multiple primary carcinomas of the larynx are not uncommon, but their exact incidence has not been clearly defined. The occurrence of an additional malignancy in the larynx should not necessarily be interpreted as a treatment failure for the initial laryngeal tumor, since the second tumor may represent a de novo primary malignancy. 'The frequency of primary or multicentric neoplastic areas in the larynx is relevant to research work on carcinogenesis and to clinical matters, such as the early detection of a second primary cancer in the respiratory tract.Patients who have had a primary cancer of the respiratory system are particularly prone to develop subsequent primary tumors elsewhere in this system. There is evidence that multiple synchronous tumors may involve the larynx -an observation that points up the relevance of the concept of "field cancerization" or "condemned mucosa" to this anatomic region.Two distinct synchronous or metachronous malignant tumors of the same histologie type (as, for example, tumors exhibiting squamous differentiation) are not rare in the larynx. Honcamp 2 observed 3 squamous carcinomas in the same larynx. Rabbet 3 reported 3 distinct primary cases of multicentric carcinoma of the larynx. Heiner 4 described a patient with 3 separate squamous carcinomas of the larynx. (The third primary malignant lesion was in situ carcinoma.) Thirty of 535 patients (5.6%) followed up over a 5-to 25-year period after treatment for carcinoma of the vocal fold developed a second primary laryngeal carcinoma. 5Second primary laryngeal cancer in limited (Tl or T2) glottic cancer has been observed in patients treated with different modalities -surgery or radiotherapy -and the incidence of a second primary laryngeal cancer is higher in the group of patients treated with surgery. In particular, in the group treated with surgery (118 patients), 9 of the 32 second primary cancers occurred in the larynx; in the group of irradiated patients (185 patients), 1 of the 23 second primary cancers occurred in the larynx. New malignancies occurring within the larynx were classified as second primary tumors if they occurred more than 5 years after treatment. 6

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“…Benigne, vor allem im Bereich der Epiglottis lokalisierte Neubildungen stellen Zysten dar, darüber hinaus wurden entzündliche Veränderungen miss-diagnostiziert. Als "Pseudolymphome", "lymphatische Hyperplasien" oder "lymphatischer Pseudotumor" werden benigne lymphoproliferative Erkrankungen bezeichnet, die ebenfalls im Kehlkopf beschrieben wurden und histologisch teilweise nur schwer von einem NHL abgegrenzt werden können [3,15,18]. Mehr als 90 % der primären Kehlkopfmalignome sind Plattenepithelkarzinome, 30 % entstehen supraglottisch, submuköse Wachstumsmuster werden ebenfalls gelegentlich beobachtet [22].…”

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Das maligne Lymphom des Larynx: Fallbericht und Literaturübersicht

Franzen¹,

Kurrer²

2000

Laryngorhinootologie

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Lymphomas primary to the larynx are non-Hodgkin-lymphomas and are predominantly located in the supraglottic larynx. The presenting symptoms and signs include dysphagia, dysphonia, dyspnea which on occasion can be severe, and enlarged cervical lymphoma. B-symptoms are mostly not present. Indirect laryngoscopy reveals a globoid submucosal faintly pink tumor mass. The diagnosis rests on histological examination of a biopsy specimen. Benign tumors, squamous cell carcinoma and other lymphoproliferative diseases have to be excluded from the differential diagnosis. Extensive tumor staging is necessary before radiotherapy or chemotherapy. Surgery is not indicated, even in localized disease. Prognosis is good in the most often localized laryngeal non-Hodgkin-lymphomas (stage IE and IIE) and generalization is rare. Hence, supraglottic submucosal laryngeal tumors can represent non-Hodgkin-lymphomas. Biopsy and subsequent histological examination are essential for correct diagnosis.

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Metachronous Coexistence of Laryngeal Pseudolymphoma and Squamous Cell Carcinoma

Cited by 10 publications

References 6 publications

Coexistence of MALT-type lymphoma and squamous cell carcinoma of the larynx

Coexistence of MALT-type lymphoma and squamous cell carcinoma of the larynx

Synchronous and Metachronous Multiple Primary Laryngeal Malignancies

Das maligne Lymphom des Larynx: Fallbericht und Literaturübersicht

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