Metachronous colorectal cancers result from missed lesions and non-compliance with surveillance

Clercq, Chantal M. C. le; Winkens, Björn; Bakker, C. M.; Keulen, Eric T.P.; Beets, Geerard L.; Masclee, Ad; Sanduleanu, Silvia

doi:10.1016/j.gie.2014.12.052

Cited by 60 publications

(60 citation statements)

References 45 publications

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“…While efforts to improve quality have focused on increased instrument withdrawal time, adenoma detection rate, and bowel prep quality, 54 reports of interval cancers in patients undergoing careful endoscopic examination show that conventional colonoscopy can be ineffective even under optimal conditions. 55,56 Other advanced endoscopic techniques, such as narrowband imaging (NBI) 57-59 and chromoendoscopy, 60-62 have been investigated in efforts to improve polyp visualization; however, these technologies do not offer much improvement in the adenoma detection rate or in patient outcomes. 63,64 …”

Section: Discussionmentioning

confidence: 99%

Design and Synthesis of Near-Infrared Peptide for in Vivo Molecular Imaging of HER2

et al. 2015

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We report the development, characterization, and validation of a peptide specific for the extracellular domain of HER2. This probe chemistry was developed for molecular imaging by using a structural model to select an optimal combination of amino acids that maximize the likelihood for unique hydrophobic and hydrophilic interactions with HER2 domain 3. The sequence KSPNPRF was identified and conjugated with either FITC or Cy5.5 via a GGGSK linker using Fmoc-mediated solid-phase synthesis to demonstrate fiexibility for this chemical structure to be labeled with different fluorophores. A scrambled sequence was developed for control by altering the conformationally rigid spacer and moving both hydrophobic and hydrophilic amino acids on the C-terminus. We validated peptide specificity for HER2 in knockdown and competition experiments using human colorectal cancer cells in vitro, and measured a binding affinity of kd = 21 nM and time constant of k = 0.14 min−1 (7.14 min). We used this peptide with either topical or intravenous administration in a preclinical model of colorectal cancer to demonstrate specific uptake in spontaneous adenomas and to show feasibility for real time in vivo imaging with near-infrared fluorescence. We used this peptide in immunofluorescence studies of human proximal colon specimens to evaluate specificity for sessile serrated and sporadic adenomas. Improved visualization can be used endoscopically to guide tissue biopsy and detect premalignant lesions that would otherwise be missed. Our peptide design for specificity to HER2 is promising for clinical translation in molecular imaging methods for early cancer detection.

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Section: Discussionmentioning

confidence: 99%

Design and Synthesis of Near-Infrared Peptide for in Vivo Molecular Imaging of HER2

et al. 2015

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“…The correlation between risk of post-colonoscopy cancer and adenoma detection rates was also reported in a study from Poland 76 . Training and quality assurance measures, and adherence to surveillance guidelines also have an impact on the rate of post-colonoscopy cancers 75,117 .…”

Section: Diagnosis Screening and Preventionmentioning

confidence: 99%

Colorectal cancer

Kuipers

Grady

Lieberman

et al. 2015

Nat Rev Dis Primers

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Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The ‘rise’ of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of art knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment.

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“…Despite the widespread use of CC, 4-20% of such examinations are incomplete, usually due to anatomical reasons (14); furthermore the discomfort involved with Abdominal pain/diverticulitis 18 [23] CRC screening 3 [4] Follow-up of X-ray findings 3 [4] Follow-up after polypectomy 2 [3] CRC, colorectal cancer; GI, gastrointestinal; IBD, inflammatory bowel disease. such procedures could deter patients from repeat attempts where necessary.…”

Section: Discussionmentioning

confidence: 99%