Metachronous early gastric cancer over a period of 13 years after eradication of Helicobacter pylori

Mitsunaga, Atsushi; Tagata, Tomoko; Hamano, Tetsuya; Teramoto, Honami; Kan, Motoyasu; Mitsunaga, Yutaka; Tobari, Maki; Shirato, Izumi; Shirato, Miho; Yoshida, Shuhei; Shimada, Masahiko; Nishino, Tomoya

doi:10.1007/s12328-014-0536-9

Cited by 4 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2); 11 % of MGCs (10 of 94) were detected more than 5 years after successful H. pylori eradication (Table 4). Several cases of MGC detected more than 10 years after successful eradication of H. pylori were also reported [35,36]. It is therefore important to perform surveillance endoscopy continuously.…”

Section: Discussionmentioning

confidence: 99%

Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan

Mori

Nakajima

Asada³

et al. 2015

Gastric Cancer

View full text Add to dashboard Cite

Background A previous multicenter prospective randomized study from Japan showed that Helicobacter pylori eradication reduced the development of metachronous gastric cancer (MGC) after endoscopic resection for early gastric cancer. MGC risk, however, is not eliminated; yet few studies have evaluated its long-term incidence and risk factors. In this study, we investigated the incidence of and risk factors for MGC in patients who underwent endoscopic resection for early gastric cancer with successful H. pylori eradication. Methods A total of 594 patients who underwent endoscopic resection for early gastric cancer and successful H. pylori eradication at three institutions (National Cancer Center Hospital, University of Tokyo Hospital, and Wakayama Medical University Hospital) were analyzed retrospectively. Annual endoscopic surveillance was performed after initial endoscopic resection. MGC was defined as a gastric cancer newly detected at least 1 year after successful H. pylori eradication. Results Ninety-four MGCs were detected in 79 patients during the 4.5-year median follow-up period. KaplanMeier analysis showed the cumulative incidence of MGC 5 years after successful H. pylori eradication was 15.0 %; the incidence of MGC calculated by use of the person-year method was 29.9 cases per 1000 person-years. Multivariate analysis using the Cox proportional hazards model revealed that male sex, severe gastric mucosal atrophy, and multiple gastric cancers before successful H. pylori eradication were independent risk factors for MGC. Eleven percent of MGCs (10 of 94) were detected more than 5 years after successful H. pylori eradication. Conclusion Surveillance endoscopy for MGC in patients who have undergone endoscopic resection for early gastric cancer should be performed even after successful H. pylori eradication.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan

Mori

Nakajima

Asada³

et al. 2015

Gastric Cancer

View full text Add to dashboard Cite

show abstract

“…It is well known that inflammation has a role in the development and progression of different cancers. Many tumors arise from sites of chronic irritation, infection, and inflammation and also inflammatory cells play important roles in the growth and progression of some tumours (Hussein and Ahmed, 2005;Aliustaoglu et al, 2010;Bae and Kim, 2014;Hoshida et al, 2014;Mitsunaga et al, 2014;Okada, 2014;Sicking et al, 2014). Infiltrates of many immune cells have been detected in malignant tissue (Yildirim et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Utility of Peripheral Blood Parameters in Predicting Breast Cancer Risk

Okuturlar

Günaldı²,

Tiken³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Purpose: We aimed to study the inflammatory parameters of complete blood count in breast cancer cases. Materials and Methods: This retrospective study covered 178 breast cancer patients and 107 age and body mass index matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR) and MPV/platelet were analyzed. Results: The leukocyte, neutrophil and neutrophil/ lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) while haemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysis showed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001 and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cutoff value for the neutrophil/lymphocyte ratio was 2.56. Conclusions: According to our study results, neutrophil levels as part of complete blood count may be used as an independent predictor of breast cancer risk.

show abstract

“… 4 , 5 , 6 , 7 Interestingly, the risk of gastric cancer development in ulcer patients with successful H pylori eradication has been reported to be reduced by only one third or less compared with eradication failure patients. 4 , 5 , 8 , 9 These results raise the hypothesis that residual abnormalities in the regenerated epithelium after ulcer healing could increase the risk of subsequent damage or disease.…”

mentioning

confidence: 88%

Epithelial Regeneration After Gastric Ulceration Causes Prolonged Cell-Type Alterations

Aihara

Matthis

Karns

et al. 2016

Cellular and Molecular Gastroenterology and Hepatology

View full text Add to dashboard Cite

Background & Aim The peptic ulcer heals through a complex process, although the ulcer relapse often occurs several years later after healing. Our hypothesis is that even after visual evidence of healing of gastric ulceration, the regenerated epithelium is aberrant for an extended interval, increasing susceptibility of the regenerated epithelium to damage and further diseases. Methods Gastric ulcers were induced in mice by serosal topical application of acetic acid. Results Gastric ulcers induced by acetic acid visually healed within 30 days. However, regenerated epithelial architecture was poor. The gene profile of regenerated tissue was abnormal, indicating increased stem/progenitor cells, deficient differentiated gastric cell types, and deranged cell homeostasis. Despite upregulation of PDX1 in the regenerated epithelium, no mature antral cell type was observed. Four months after healing, the regenerated epithelium lacks parietal cells, TFF2 and SOX9 remain upregulated deep in the gastric gland, and the Na/H exchanger 2 (a TFF2 effector in gastric healing) remains downregulated. Gastric ulcer healing was strongly delayed in TFF2 knockout mice, and re-epithelialization was accompanied with mucous metaplasia. Following H. pylori inoculum 30 days after ulceration, we observed that the gastric ulcer selectively relapses at the same site where it was originally induced. Follow up at 8 months showed that the relapsed ulcer was not healed in H. pylori infected tissues. Conclusion These findings reveal that this macroscopically regenerated epithelium has prolonged abnormal cell distribution and is differentially susceptible to subsequent damage by H. pylori.

show abstract

Metachronous early gastric cancer over a period of 13 years after eradication of Helicobacter pylori

Cited by 4 publications

References 13 publications

Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan

Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan

Utility of Peripheral Blood Parameters in Predicting Breast Cancer Risk

Epithelial Regeneration After Gastric Ulceration Causes Prolonged Cell-Type Alterations

Contact Info

Product

Resources

About