Metachronous gastric MALT lymphoma and early gastric cancer: is residual lymphoma a risk factor for the development of gastric carcinoma?

Abstract

Prolonged residual GML could constitute an additional risk factor for the development of gastric carcinoma. Long-term endoscopic surveillance is mandatory in patients treated conservatively for gastric MALT lymphoma.

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

“…Longer follow-up is needed, however, to determine its long-term efficacy and to quantify the risk for late side effects. Although the risk for second malignancies is low [84], this cannot be neglected, especially in patients who may already have an increased incidence of gastric cancer, because of the link between H. pylori infection and the development of gastric adenocarcinoma [85,86]. Remission with chemotherapy has been described in a patient who relapsed following partial gastrectomy and postoperative radiation [87].…”

Second Gastric Cancer After the Treatment of Primary Stomach Diffuse Large B-Cell Lymphoma

“…This risk is increased by combination therapy including chemotherapy and radiation therapy [1,3,8]. Chemotherapy is not known to induce solid tumors, but can potentiate the effect of other treatments [8,14]. In a study of about 139 patients treated for gastric lymphoma, the authors found that CHOP type chemotherapy is associated with a higher risk of second gastric cancer (p=0.009) [13].…”

“…In a study of about 139 patients treated for gastric lymphoma, the authors found that CHOP type chemotherapy is associated with a higher risk of second gastric cancer (p=0.009) [13]. Further, it is possible that alkylating agents exert a mutagenic and carcinogenic effect [1,3,7,14].…”

“…This period was 11 years in our case. However this period was only 3 to 4 years for type MALT lymphomas [4,8,14].…”

Diagnosis and therapeutic management of gastric MALT lymphoma

“…Les patients atteints d'un LGM sont à risque de dé velopper un second cancer [18] mais é galement et surtout un cancer gastrique. Celui-ci peut ê tre synchrone [18] ou mé tachrone [7]. La surveillance endoscopique doit permettre de le dé pister au stade pré coce et espé rer une gué rison complè te au prix d'une gastrectomie totale.…”