Metachronous hepatic metastases from gastric carcinoma: A multicentric survey

Ga, Tiberio; Coniglio, Arianna; Marchet, Alberto; Marrelli, Daniele; Giacopuzzi, Simone; Baiocchi, Gian Luca; Roviello, Franco; Manzoni, Giovanni De; Nitti, Donato; Sm, Giulini

doi:10.1016/j.ejso.2008.12.017

Cited by 63 publications

(68 citation statements)

References 15 publications

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“…The significant benefit that we found in our patient group with metachronous metastasis was not found in the other studies [24][25][26][27]. The influence of solitary and multiple metastases on survival is controversial.…”

Section: Comparative Literaturecontrasting

confidence: 71%

Outcome of Operative Therapy of Hepatic Metastatic Stomach Carcinoma: A Retrospective Analysis

et al. 2012

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The overall survival in our study was 13%; therefore gastric cancer with liver metastases is not in every case a palliative situation. It seems that patients with liver metastases benefit from resection, especially if the metastases are metachronous (p < 0.001) and solitary, provided that a curative R0 resection has been achieved. An interdisciplinary approach with neoadjuvant chemotherapy appears useful. Additional controlled studies should be conducted.

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Section: Comparative Literaturecontrasting

confidence: 71%

Outcome of Operative Therapy of Hepatic Metastatic Stomach Carcinoma: A Retrospective Analysis

et al. 2012

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“…This finding is not consistent with other studies [17,18] . However, we have not found the proper explanation for this phenomenon.…”

Section: Discussioncontrasting

confidence: 82%

Recurrent patterns and factors involved in node-negative advanced gastric cancer

Liu

Zhong

Liu

et al. 2010

Chin. J. Cancer Res.

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Objective:To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection.Patients and Methods: Clinicopathological characteristics and prognostic outcomes of 310 patients who had lymph node-negative advanced gastric adenocarcinoma and received curative resection between 2002 and 2006 were retrospectively evaluated.Results: Among the 300 patients, 15 (5.0%) had locoregional recurrence, 5 (1.7%) had lymph node recurrence, 27 (9.0%) had peritoneal seeding recurrence, and 21 (7.0%) had hematogenous metastasis. Using multivariate analysis, we found that the maximum tumor diameter (P=0.014), histological type (P=0.001) and Borrmann type (P=0.033) were independent factors predicting the locoregional recurrence. Lymph node recurrence was significantly affected by lymph node dissection (P=0.029) and lymphovascular invasion (P=0.004). Clinicopathological factors predicting the peritoneal seeding recurrence were the depth of invasion (P=0.001) and Borrmann type (P=0.002). In addition, lymphovascular invasion (P=0.013) and histological type (P=0.001) were significantly associated with hematogenous metastasis.Conclusion: Node-negative advanced gastric cancer has a high amount of peritoneal seeding and hematogenous metastasis.

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“…Those results were maintained after propensity matching for the differences between groups. Other publications from the Far East [4][5][6][7], and some Western centers [14][15][16][17], have also suggested the safety of hepatectomy for gastric cancer liver metastases in selected patients. The results of this study also parallel the outcomes of hepatectomy for colorectal cancer liver metastases, where surgical resection is more common and is considered the standard of care for isolated hepatic metastases [11].…”

Section: Discussionmentioning

confidence: 99%

Surgical resection of hepatic metastases from gastric cancer: outcomes from national series in England

et al. 2016

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Background The objectives of this national study were to examine the short-term safety and long-term survival benefit associated with surgical resection of hepatic metastases from gastric cancer. Methods Patients from the Hospital Episode Statistics database were classified by disease and treatment approach. Gastric cancer: 1. Without liver metastases treated by gastrectomy (GG). 2. With liver metastases treated by gastrectomy and hepatectomy (GGH). 3. With liver metastases treated by gastrectomy without hepatectomy (GGNH). 4. With liver metastases treated with no surgery (GNS). Propensity score matching and multivariable analyses were used to compensate for differences in some baseline characteristics. Results During the study period, 87,482 were patients diagnosed with gastric cancer, of whom 13,841 underwent partial or total gastrectomy. Of those who underwent gastrectomy, 336 had a diagnosis of liver metastases and 78 of these had a hepatectomy. Propensity-matched analysis showed no significant differences in 30-or 90-day mortality between the GGH and GG groups. The GGH group had significantly improved 1-year mortality (35.9 % vs. 50.0 %, p = 0.049) and 5-year mortality (61.5 % vs. 75.7 %, p = 0.031) compared to the GGNH group, and compared to the GNS group, the GCH group had 1-year mortality (35.9 % vs. 84.6 %, p \ 0.001) and 5-year mortality (61.5 % vs. 90.8 %, p \ 0.001). Conclusions This study showed that hepatectomy for synchronous gastric cancer hepatic metastases may carry survival benefits in selected patients. The data presented should not be a rationale to change current clinical practice but rather a stimulus to prospectively study the role of surgery in a selected group of patients who are currently treated with palliative chemotherapy.

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Metachronous hepatic metastases from gastric carcinoma: A multicentric survey

Cited by 63 publications

References 15 publications

Outcome of Operative Therapy of Hepatic Metastatic Stomach Carcinoma: A Retrospective Analysis

Outcome of Operative Therapy of Hepatic Metastatic Stomach Carcinoma: A Retrospective Analysis

Recurrent patterns and factors involved in node-negative advanced gastric cancer

Surgical resection of hepatic metastases from gastric cancer: outcomes from national series in England

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