Metachronous Pancreatic Adenocarcinoma in Patient with Renal Cell Carcinoma: A Case Report

Jindal, Satya Prakash; Adithya, GK; Madaan, Varun; Tandon, Vivek; Govil, Deepak

doi:10.7860/jcdr/2018/34297.11978

Cited by 1 publication

(2 citation statements)

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“…Although, exact factors for the development of PDAC are not known, common risk factors are age, smoking, obesity and chronic pancreatitis. Five percent of all cases of PDAC are associated with genetic disorders [6]. The patient does not have any of the known risk factors for developing pancreatic cancer and genetic testing was negative, making more prone a de novo mutation.…”

Section: Discussionmentioning

confidence: 96%

“…There are several factors associated to the presence of a second or third primary malignancy, like Caucasian race, family history of malignancies and non-aggressive neoplasia [11]. The associated mechanisms to the development of MPM are classified in three categories: associated to the treatment of the first malignancy, associated to a syndrome and associated to epigenetics such as life style, environmental exposure and genetic mutation [6]. In the patient an association with epigenetics is more probable because he did not receive any treatment for the first primary malignancy and no known genetic mutation associated with neither of the three types of cancer was found in patient DNA analysis.…”

Section: Discussionmentioning

confidence: 99%

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Metachronous Pancreatic Adenocarcinoma in Patient with Prostatic Carcinoma, Multiple Primary Malignancies: Case Report

Palacios¹,

Arias²,

Celi³

2018

J Tumor Res

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Multiple primary malignancy is two or more primary tumors that are diagnosed simultaneous or metachronous. The incidence rises with advanced age and is more common in men despite the high rate of prostatic cancer and its co-occurrence with other type of cancer. Multiple primary malignancy is an increasingly frequent event due to the advance's diagnostic methods, but whenever found they arise questions of possible common etiologies or same pathogenic mechanisms. We reported a case of a 66 years old male patient presented with painless asymptomatic pancreatic mass which was found as an incidental finding in a checkup for surgery for prostatic adenocarcinoma, T3NOMO. A pancreatoduodenectomy was done and histopathological results showed a pancreatic adenocarcinoma, T1N0M0, and an intraductal papillary mucinous neoplasm, T1N0M0. The patient was diagnosed with a metachronous multiple primary malignancy. Few combinations are labelled as syndromes or showed a common genetic association; however, sporadic cases of multiple primary malignancy are relatively rare. Such a combination of prostatic carcinoma and pancreatic carcinoma is sparingly being reported.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%