Metachronous Synchronous Sternal and Colonic Metastasis with Asymptomatic Colo-colic Fistula from Carcinoma Ovary Rare Presentation of Ovarian Cancer

Abstract

Ovarian cancer is one of the most common gynecological cancers worldwide. It is the third leading cause of cancer among women in India. Metastatic disease to the visceral organs from ovarian cancer occurs as a terminal event in the natural history of the disease. In particular, spread to the bone and large bowel is infrequently described. The risk of distant metastasis increases in a recurrent setting. We describe a case of a 77-year-old lady, who was diagnosed for ovarian carcinoma in 2007 and underwent primary cytoreductive surgery, stage IIIc. She presented to us with asymptomatic rising cancer antigen (CA) 125 levels during follow-up. On evaluation she was found to have sternal and colonic deposits. She underwent left hemicolectomy and biopsy of sternal deposit. Histopathology revealed metastasis from the carcinoma ovary to the colon and sternum. This case report highlights the rare synchronous metastatic disease in a metachronous setting from ovarian carcinoma.

Correlation of LAMA3 with onset and prognosis of ovarian cancer

“…Surgical resection is the most effective therapeutic method for ovarian cancer currently, which, however, will lead to various sequelae, such as obesity, hypertension, heart disease and osteoporosis (15). In terms of drug therapy, chemotherapeutic drugs applied clinically are harmful to the body's immune system, and the emerging cell therapy has obtained a certain effect only in in vitro experiments and animal experiments, but its anti-solid tumor effect in the human body is still unsatisfactory (16,17). Therefore, studying the pathogenesis to clarify the correlation between gene and onset is of great significance in the prevention of disease and development of targeted drugs.…”