Metaciclogênese do Trypanosoma cruzi como parâmetro de interação do parasita com o triatomíneo vetor

Alvarenga, Nelson J.; Bronfen, Elisabeth

doi:10.1590/s0037-86821997000300012

Cited by 16 publications

(10 citation statements)

References 4 publications

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“…These are then eliminated through the feces and urine of the vectors 96,97 . This process involves a series of biochemical and immunological mechanisms, in which the enzymes, hemolysins, agglutinins and other antimicrobacterial agents have still not been properly investigated 98 .…”

Section: Metacyclogenesis Of T Cruzi In Different Species Of Triatommentioning

confidence: 99%

Chagas disease: What is known and what should be improved: a systemic review

Coura

Borges-Pereira

2012

Rev. Soc. Bras. Med. Trop.

118

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This study consists of a broad review on what is known and what should be improved regarding knowledge of Chagas disease, not only through analysis on the main studies published on the topics discussed, but to a large extent based on experience of this subject, acquired over the past 50 years (1961-2011). Among the subjects covered, we highlight the pathogenesis and evolution of infection by Trypanosoma cruzi, drugs in use and new strategies for treating Chagas disease; the serological tests for the diagnosis and the controls of cure the infection; the regional variations in prevalence, morbidity and response to treatment of the disease; the importance of metacyclogenesis of T. cruzi in different species of triatomines and its capacity to transmit Chagas infection; the risks of adaptation of wild triatomines to human dwellings; the morbidity and need for a surveillance and control program for Chagas disease in the Amazon region and the need to prioritize initiatives for controlling Chagas disease in Latin America and Mexico and in non-endemic countries, which is today a major international dilemma. Finally, we raise the need for to create a new initiative for controlling Chagas disease in the Gran Chaco, which involves parts of Argentina, Bolivia and Paraguay.

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Section: Metacyclogenesis Of T Cruzi In Different Species Of Triatommentioning

confidence: 99%

Chagas disease: What is known and what should be improved: a systemic review

Coura

Borges-Pereira

2012

Rev. Soc. Bras. Med. Trop.

118

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“…Epimastigote forms of the T. cruzi clone Dm28c 29 and T. cruzi Y 30 strain were obtained from the Laboratory of Cellular Ultrastructure, FIOCRUZ. L. infantum MHOM/BR/1974/PP75 and L. amazonensis IFLA/BR/1967/PH8 were donated by the Leishmania Type Culture Collection (LTCC) of Oswaldo Cruz Institute/Fiocruz (Rio de Janeiro, Brazil).…”

Section: Methodsmentioning

confidence: 99%

Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases fromTrypanosoma cruziandLeishmania donovani

Nocentini

Osman

Rodrigues

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

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Chagas disease and leishmaniasis are neglected tropical disorders caused by the protozoans Trypanosoma cruzi and Leishmania spp. Carbonic anhydrases (CAs, EC 4.2.1.1) from these protozoans (α-TcCA and β-LdcCA) have been validated as promising targets for chemotherapic interventions. Many anti-protozoan agents, such as nitroimidazoles, nifurtimox, and benznidazole possess a nitro aromatic group in their structure which is crucial for their activity. As a continuation of our previous work on N -nitrosulfonamides as anti-protozoan agents, we investigated benzenesulfonamides bearing a nitro aromatic moiety against TcCA and LdcCA, observing selective inhibitions over human off-target CAs. Selected derivatives were assessed in vitro in different developmental stages of T. cruzi and Leishmania spp. A lack of significant growth inhibition has been found, which has been connected to the low permeability of this class of derivatives through cell membranes. Further strategies necessarily need to be designed for targeting Chagas disease and leishmaniasis with nitro-containing CA inhibitors.

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“…Epimastigote forms of the T. cruzi clone Dm28c (lineage TCII) 31 and Y(lineage TCI) 32,33 strains obtained from the Laboratory of Figure 1. Preparation of nanoemulsion by high-energy method.…”

Section: T Cruzi Parasitesmentioning

confidence: 99%

Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi

Vermelho

Cardoso

Ricci

et al. 2017

Journal of Enzyme Inhibition and Medicinal Chemistry

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Sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors targeting the α-class enzyme from the protozoan pathogen Trypanosoma cruzi, responsible of Chagas disease, were recently reported. Although many such derivatives showed low nanomolar activity in vitro, they were inefficient anti-T. cruzi agents in vivo. Here, we show that by formulating such sulfonamides as nanoemulsions in clove (Eugenia caryophyllus) oil, highly efficient anti-protozoan effects are observed against two different strains of T. cruzi. These effects are probably due to an enhanced permeation of the enzyme inhibitor through the nanoemulsion formulation, interfering in this way with the life cycle of the pathogen either by inhibiting pH regulation or carboxylating reactions in which bicarbonate/CO are involved. This type of formulation of sulfonamides with T. cruzi CA inhibitory effects may lead to novel therapeutic approaches against this orphan disease.

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Metaciclogênese do Trypanosoma cruzi como parâmetro de interação do parasita com o triatomíneo vetor

Abstract: SUMMARY Infection of

Cited by 16 publications

References 4 publications

Chagas disease: What is known and what should be improved: a systemic review

Chagas disease: What is known and what should be improved: a systemic review

Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases fromTrypanosoma cruziandLeishmania donovani

Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi

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