Metadoxine Versus Placebo for the Treatment of Non-alcoholic Steatohepatitis: A Randomized Controlled Trial

Abstract

Metadoxine is not effective in improvement of liver histology or serum ALT or AST in patients with NASH. However, there was significant improvement of steatosis assessed by ultrasound. To properly estimate the effects on histology and transaminases, further studies of longer duration and at higher doses are needed.

Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD)

“…Uses of intervention and comparator of 44 included studies[ 8 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 ] are summarized in Table 1  . Among them, 35, 8, and 1 study were 2-arm,[ 8 28 29 30 31 33 35 37 38 39 42 43 44 45 46 47 48 49 50 51 52 54 55 56 59 60 61 62 63 64 66 67 68 69 70 ] 3-arm,[ 32 34 40 41 53 57 58 65 ] and 4-arm [36] RCTs, respectively.…”

“…Among them, 35, 8, and 1 study were 2-arm,[ 8 28 29 30 31 33 35 37 38 39 42 43 44 45 46 47 48 49 50 51 52 54 55 56 59 60 61 62 63 64 66 67 68 69 70 ] 3-arm,[ 32 34 40 41 53 57 58 65 ] and 4-arm [36] RCTs, respectively. Among 2-arm RCTs, 31 and 4 RCTs were placebo and active controls, respectively.…”

“…Among 2-arm RCTs, 31 and 4 RCTs were placebo and active controls, respectively. Among 31 placebo controls, following various interventions were used: 8 studies for weight/lipid controls,[ 42 43 48 49 50 54 64 70 ] 3 studies for TZD,[ 29 31 55 ] and PTX,[ 56 67 69 ] 4 studies for Met,[ 39 62 63 66 ] and PUFA,[ 30 33 45 52 ] 2 studies for antioxidants,[ 47 68 ] UDCA,[ 44 46 ] vitamin E/vitamin C,[ 38 51 ] and other groups including betaine, [28] metadoxine, [61] and OCA, [8] respectively. Among 4 trials of 2-arm RTCs with active controls, their interventions and active comparators were as follows: telmisartan versus valsartan, [35] vitamin E versus bicyclol, [37] vitamin E versus vitamin E/TZD, [59] and TZD versus PTX.…”

“…A total of 21 studies[ 8 29 30 31 33 38 39 40 41 42 46 48 51 55 58 61 65 66 67 69 70 ] (n = 1939 patients) reported improvement in fibrosis from 12 interventions (Fig. 1A).…”

Encuesta sobre el uso de la metadoxina en hepatopatías de pequeños animales en Colombia

“…Además, previene la depleción de ATP, glutatión y glicógeno; aminora el grado de esteatosis y la inducción de la secreción de TNF-alfa (10,(13)(14)(15), mientras tiene el potencial de cumplir funciones antifibróticas y antinecróticas in vitro (11,12,16). Dichas ventajas se han evaluado en ensayos clínicos controlados y metaanálisis en humanos (2,(5)(6)(7)(10)(11)(12)(13)(14)16). No obstante, en medicina veterinaria no hay publicaciones de su indicación terapéutica en buscadores biomédicos anglosajones como PubMed, Science Direct, Wiley, EBSCO, SciELO y Google Scholar que incluyan términos MeSH como "Metadoxine and canine" o "Metadoxine and veterinarian".…”