Lakes are important natural sources of greenhouse gases (GHGs) to the atmosphere, and their nutrient status is a significant driver affecting GHGs production and emission. Nevertheless, when estimating GHGs emissions at regional or national scales, the variations in emission rates caused by differences in nutrient status are often overlooked or not adequately considered. The potential social benefits of eutrophication control in mitigating climate change damage were rarely quantified, leading to largely underestimated benefits generated from water quality improvement. In this study, we compiled a comprehensive dataset on the emission rates of three typical GHGs (i.e., CO2, CH4, and N2O) from China’s lakes (n=356), and their nutrient concentrations, lake morphologies, and climate information. The fitted models between lake GHG emission rates and their drivers were established to upscale national GHGs emissions from lakes and approximate the changes in GHGs emissions under different nitrogen and phosphorus levels. We found that the current GHGs emissions from China’s lakes were 48.44 (31.60‒73.79) Tg CO2-eq·y-1, with CO2 emissions contributing around 52%. Even with a mere 10% reduction in nitrogen concentration in lakes nationwide over 2020‒2050, the estimated decrease in the GHGs emissions over the 30-year period would be 46.9 Tg CO2-eq, avoided climate change damages values could reach $1.5‒4.9 billion (2020 $US). Lake eutrophication controls can present an excellent chance to simultaneously achieve the Sustainable Development Goals of “clean water and sanitation” and “climate action”, accelerating the global progress toward sustainability.