Metagenomic characterization of indoor dust fungal associated with allergy and lung inflammation among school children

Isa, Khairul Nizam Mohd; Jalaludin, Juliana; Elias, Saliza Mohd; Than, Leslie Thian Lung; Jabbar, Mohammed Abdulrazzaq; Saudi, Ahmad Shakir Mohd; Norbäck, Dan; Hashim, Jamal Hisham; Hashim, Zailina

doi:10.1016/j.ecoenv.2021.112430

Cited by 6 publications

(4 citation statements)

References 80 publications

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“…The airway mycobiota was a diverse population with a significant degree of individual variation. Significant alterations in the fungus found in the lung were related to the severity and longevity of asthma and inflammatory markers [27,58].…”

Section: Fungal Microbiome (Mycobiome)mentioning

confidence: 99%

“…The airway inflammation that was caused by eosinophil and neutrophil activation and degranulation markers is associated with exposure to particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM 2.5 ), nitrogen dioxide (NO 2) , Trichosporon asahii, Papiliotrema bandonii, and Aspergillus clavatus. Furthermore, it was shown that there is a correlation between the asthma phenotype and indoor pollutants, in which a fungi profile can be identified [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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The Fungal and Bacterial Interface in the Respiratory Mycobiome with a Focus on Aspergillus spp.

Antariksa

Nurwidya

Zaini

et al. 2023

Life

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The heterogeneity of the lung microbiome and its alteration are prevalently seen among chronic lung diseases patients. However, studies to date have primarily focused on the bacterial microbiome in the lung rather than fungal composition, which might play an essential role in the mechanisms of several chronic lung diseases. It is now well established that Aspergillus spp. colonies may induce various unfavorable inflammatory responses. Furthermore, bacterial microbiomes such as Pseudomonas aeruginosa provide several mechanisms that inhibit or stimulate Aspergillus spp. life cycles. In this review, we highlighted fungal and bacterial microbiome interactions in the respiratory tract, with a focus on Aspergillus spp.

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Section: Fungal Microbiome (Mycobiome)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Fungal and Bacterial Interface in the Respiratory Mycobiome with a Focus on Aspergillus spp.

Antariksa

Nurwidya

Zaini

et al. 2023

Life

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show abstract

“…The TSI Optical Particle Sizer Model 3330 is utilized for air sampling, specifically for collecting fine and ultrafine particles such as PM 2.5 and PM 10 designed to measure the size distribution and concentration of airborne particles, including those in the nano-size range (22). On the other hand, the TSI Model 9565-A Velocicalc Multi-Function Ventilation Meter is primarily used for measuring different parameters related to indoor air quality and ventilation, including air velocity, temperature, and humidity (23). Although it is not typically used for collecting or measuring pollutants, it can be used to evaluate ventilation system performance and indoor air quality.…”

Section: Indoor Air Quality Samplingmentioning

confidence: 99%

Association Between Air Microbiological Exposure With Sick Building Syndrome (SBS) among College Dormitory Students in Public University

Abdul Rahim,

Jalaludin,

Junaidi

et al. 2023

MJMHS

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Introduction: Microbiological pollutants in indoor air can lead to sick building syndrome (SBS). A conducive academic environment in university dormitories requires healthy indoor air quality to enhance student performance. This study aimed to determine the association between indoor air microbiological exposure and SBS among college dormitory students at a public university. Methods: A cross-sectional study was conducted among 112 male and female college dormitory students who stayed in the public university dormitory for more than three months. Respondents were given a self-administered questionnaire-based NIOSH Indoor Environmental Quality Survey. 14 houses were selected for the measurement of indoor air quality which included PM2.5, PM10, relative humidity (%), temperature (°C), air velocity (m/s), indoor bacterial concentration (cfu/m3), and indoor mould concentration (cfu/m3). Results: Higher percentages of SBS symptoms were reported among female (94.6%) college dormitory students compared to male (82.1%). A significant difference in itching symptom on the arms and forearms was found among individuals of different genders (p<0.05). Indoor air parameters such as temperature (OR = 2.56, 95% CI = 2.66-9.87), relative humidity (OR = 1.77, 95% CI = 1.54 – 5.79), indoor bacteria concentration (OR=2.28, 95% CI = 2.48 – 10.93), and indoor mould concentration (OR=2.59, 95% CI = 1.75 – 8.98) were significantly associated with the recent SBS symptoms. Multiple logistic regression showed that the most significant predictor of SBS was indoor mould concentration. Conclusion: Exposure to high concentrations of indoor bacteria and mould, high temperatures, and high relative humidity influenced the prevalence of SBS among college dormitory students. Further assessment and preventive action need to be taken to reduce the exposure of indoor air microbiological to the students.

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“…Finally, MicrobiomeAnalyst, a web-based platform was used to generate taxa abundance plots, rarefaction curves and alpha diversity from QIIME2. More extensive information on fungal genome DNA extraction and bioinformatics sequence analysis could be found in our previous publication (Mohd Isa et al, 2021).…”

Section: Dna Extraction and Amplicon Sequencing Analysismentioning

confidence: 99%

Fungi composition in settled dust associated with fractional exhaled nitric oxide in school children with asthma

Isa

Jalaludin²,

Hashim³

et al. 2022

Science of The Total Environment

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Metagenomic characterization of indoor dust fungal associated with allergy and lung inflammation among school children

Cited by 6 publications

References 80 publications

The Fungal and Bacterial Interface in the Respiratory Mycobiome with a Focus on Aspergillus spp.

The Fungal and Bacterial Interface in the Respiratory Mycobiome with a Focus on Aspergillus spp.

Association Between Air Microbiological Exposure With Sick Building Syndrome (SBS) among College Dormitory Students in Public University

Fungi composition in settled dust associated with fractional exhaled nitric oxide in school children with asthma

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