Metal Allergy and Contact Urticaria

Bennike, Niels H.; Foss-Skiftesvik, Majken H.

doi:10.1007/978-3-319-58503-1_40

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Nickel allergy is usually reported as contact dermatitis of Type IV hypersensitivity and to a lower incidence, Type I hypersensitivity. While Type IV hypersensitivity is mediated by hapten-specific T cells (Aparicio-Soto et al, 2020;Büdinger and Hertl, 2000;Büdinger et al, 2001;Saito et al, 2016;Schmidt et al, 2010), Type I nickel hypersensitivity is IgE-mediated (Bennike and Foss-Skiftesvik, 2018;Dolovich et al, 1984;Kolberg et al, 2020;Malo et al, 1982;Nieboer et al, 1984;Novey et al, 1983;Saluja et al, 2016;Sastre et al, 2001;Shirakawa et al, 1990). Increasingly, associations between Type IV and Type I hypersensitivities to nickel in populations are reported (Gelardi et al, 2017;Kolberg et al, 2020), with evidence of both type I and IV hypersensitivity occurring within the same patient (Walsh et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity

Lua

Poh

et al. 2020

Preprint

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Nickel (Ni) allergy has been reported in contact dermatitis Type IV (Ni-specific T cells mediated) and asthmatic Type I (IgE-mediated) hypersensitivities. Associations between the two hypersensitivities have been found in some patients, but the underlying mechanisms remain enigmatic. Using Her2-specific IgEs as models, we found additional binding to Ni-NTA without observable changes in binding to Her2 and that glutamine, together with the canonical Ni2+-binding histidine, could form Ni2+ binding signatures. This mechanism may underlie Type I hypersensitivity in the selection of anti-Ni2+ IgEs. This mechanism may also underlie Type IV hypersensitivity and the interaction of immunoglobulin proteins with other heavy metal ions. Our findings shed light to how Ni hypersensitivities can occur and how they can be avoided in therapeutics design, or even incorporated for biotechnological purification purposes.

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Section: Introductionmentioning

confidence: 99%

Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity

Lua

Poh

et al. 2020

Preprint

View full text Add to dashboard Cite

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Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

et al. 2019

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Nickel is the most frequent cause of contact allergy worldwide and has been studied extensively. This clinical review provides an updated overview of the epidemiology, exposure sources, methods for exposure quantification, skin deposition and penetration, immunology, diagnosis, thresholds for sensitization and elicitation, clinical pictures, prevention, and treatment. The implementation of a nickel regulation in Europe led to a decrease in the prevalence of nickel allergy, and changes in the clinical picture and disease severity. Nevertheless, the prevalences of nickel allergy in the European general population are approximately 8% to 19% in adults and 8% to 10% in children and adolescents, with a strong female predominance. Well‐known consumer items such as jewellery and metal in clothing are still the main causes of nickel allergy and dermatitis, although a wide range of items for both private and occupational use may cause dermatitis. Allergic nickel dermatitis may be localized to the nickel exposure site, be more widespread, or present as hand eczema. Today, efficient methods for exposure quantification exist, and new insights regarding associated risk factors and immunological mechanisms underlying the disease have been obtained. Nevertheless, questions remain in relation to the pathogenesis, the persistent high prevalence, and the treatment of severe cases.

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Metal Allergy and Contact Urticaria

Cited by 2 publications

References 32 publications

Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity

Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity

Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

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