Metal and Ceramic Implants

Hildebrand, Hartmut F.

doi:10.1002/9783527619634.ch17

Cited by 2 publications

(5 citation statements)

References 70 publications

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“…Nevertheless, this matter does not concern potential toxic effects of implantable biomedical devices. Moreover, these alloys do not contain vanadium, which has been shown to induce some cytotoxic effects in vanadium-enriched alloys [4,5,36,37,50]. The present experiences confirm that the 4% vanadium content in the Ti6Al4V alloy is not high enough or is physically so well integrated in this alloy that it does not generate any unwanted biological effect in any of the cell culture systems used.…”

Section: The Role Of the Other Alloy Compoundssupporting

confidence: 54%

“…In the second case, all osteoblasts adhere on the material surface in tight contact and are subsequently directly exposed to the chemical surface compounds. The existing extracellular matrix is not strong or tight enough to hinder the passage of released cytotoxic ions such as Cr, Ni or Co [36,37], although there could exist doubts whether in vitro proliferation differences of around 20% for CEM (between stainless steel and cp-Ti or Ti6Al4V) really represent true in vivo response. The difference rises to 60% for osteoblasts.…”

Section: Cell Responsementioning

confidence: 99%

“…Nb, Ta, Zr used in low concentrations in some alloys, is not really known. Some experimental assays and few clinical and occupational observations have shown that these metals and their compounds do not induce significant toxic effects [36,37] but improve the material-biosystem interactions.…”

Section: The Role Of the Other Alloy Compoundsmentioning

confidence: 99%

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The corrosion and biological behaviour of titanium alloys in the presence of human lymphoid cells and MC3T3-E1 osteoblasts

Zhang

Chai²,

Hornez³

et al. 2008

Biomed. Mater.

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Corrosion behaviour of biomedical alloys is generally determined in mineral electrolytes: unbuffered NaCl 0.9% (pH 7.4) or artificial saliva (pH 6.8). The assays with exclusive utilization of these electrolytes are of low relevance for the biological condition, to which the alloys will be exposed once implanted in the human organism. As an approach to the biological situation regarding the interaction of proteins, electrolytes and metals, we added the RPMI cell culture medium containing foetal calf serum as a biological electrolyte (pH 7.0). The analysis of corrosion behaviour was also performed in the presence of human lymphoid cells (CEM). The rest potential (Er) and the global polarization were determined on cp-Ti, micro-arc oxidized cp-Ti (MAO-Ti), four different Ti-alloys (Ti6Al4V, Ti12Zr, Ti(AlMoZr), Ti(NbTaZr)) and 316L stainless steel. The 316L exhibited an appropriate Er and a good passive current density (Ip), but a high corrosion potential (Ec) and a very low breakdown potential (Eb) in all electrolytes. All Ti-alloys exhibited a much better electrochemical behaviour: better Er and Ec and very high Eb. No significant differences of the above parameters existed between the Ti-alloys, except for Zr-containing alloys that showed better corrosion behaviour. A remarkable difference, however, was stated with respect to the electrolytes. NaCl 0.9% induced strong variations between the Ti-alloys. More homogeneous results were obtained with artificial saliva and RPMI medium, which induced a favourable Ec and an increased Ip. The presence of cells further decreased these values. The unbuffered NaCl solution seems to be less appropriate for the analysis of corrosion of metals. Additional in vitro biological assessments with CEM cell suspensions and MC3T3-E1 osteoblasts confirmed the advantages of the Ti(AlMoZr) and Ti(NbTaZr) alloys with an improved cell proliferation and vitality rate.

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Section: The Role Of the Other Alloy Compoundssupporting

confidence: 54%

Section: Cell Responsementioning

confidence: 99%

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The corrosion and biological behaviour of titanium alloys in the presence of human lymphoid cells and MC3T3-E1 osteoblasts

Zhang

Chai²,

Hornez³

et al. 2008

Biomed. Mater.

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“…We have to note the undesirable behavior of conventional stent material, i.e. stainless steel, which is dominated by its nickel component; this induces redox reaction and hydrolysis by electron or proton exchange and forms metallo‐organic molecular complexes while interacting with living tissue 38. Because none of the above mentioned reactions are observed with titanium, the application of the titanium‐based alloys in stents has been highly recommended 39.…”

Section: Discussionmentioning

confidence: 99%

“…stainless steel, which is dominated by its nickel component; this induces redox reaction and hydrolysis by electron or proton exchange and forms metallo-organic molecular complexes while interacting with living tissue. 38 Because none of the above mentioned reactions are observed with titanium, the application of the titanium-based alloys in stents has been highly recommended. 39 However, some studies implied potential thrombogenicity of titanium 40 and its surface characteristics should be further improved.…”

Section: Discussionmentioning

confidence: 99%

Improving endothelial cell adhesion and proliferation on titanium by sol–gel derived oxide coating

Chai

Ochsenbein

Traisnel

et al. 2009

J Biomedical Materials Res

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In-stent restenosis becomes increasingly prevalent as a difficult-to-treat disease. An alternative therapeutic strategy is enhancing endothelialization on metallic stent surfaces. This study attempted to modify surface chemistry and topography of commercial pure titanium (cp-Ti) by different sol-gel derived oxide coatings (TiO(2), SiO(2), SiO(2)/TiO(2), and Nb(2)O(5)) to improve endothelialization. The physiochemical properties of the modified surfaces were characterized by ellipsometry, atomic force microscope, and sessile-drop method. The cell adhesion/proliferation quantity, cell adhesion morphology, and focal adhesion protein expression were evaluated with human pulmonary microvascular endothelial cell line. The thickness of oxide coatings approximates to 100 nm; significantly rougher nanoporous structure was found in the TiO(2) and Nb(2)O(5) coatings than that of cp-Ti. SiO(2) coating possesses the highest surface energy (75.1 mJ/m(2)) and the lowest was for cp-Ti (45.7 mJ/m(2)). TiO(2) coating showed significantly higher endothelial cell adhesion rate than others; TiO(2), Nb(2)O(5), and TiO(2)/SiO(2) coatings exhibited higher endothelial proliferation in 3-day assays than noncoated Ti. In hemocompatible test, they also showed good hemocompatibility. These results offer the insight into that certain oxide coatings on titanium could significantly improve endothelial cell adhesion and proliferation especially in early period, which will favor reaching the endothelialization rapidly and suitable as matrix for "endothelial seeding" stent.

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Metal and Ceramic Implants

Cited by 2 publications

References 70 publications

The corrosion and biological behaviour of titanium alloys in the presence of human lymphoid cells and MC3T3-E1 osteoblasts

The corrosion and biological behaviour of titanium alloys in the presence of human lymphoid cells and MC3T3-E1 osteoblasts

Improving endothelial cell adhesion and proliferation on titanium by sol–gel derived oxide coating

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