Metal- and metal/oxide-based engineered nanoparticles and nanostructures: a review on the applications, nanotoxicological effects, and risk control strategies

Solano, Ricardo; Patiño-Ruiz, David; Benítez, Lesly Patricia Tejeda; Herrera, Adriana

doi:10.1007/s11356-021-12996-6

Cited by 37 publications

(19 citation statements)

References 212 publications

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“…In the last few decades, the development of nanotechnology and its role in subsequent applications have increased the exposure of NPs to the environment and human beings. The occurrence of NPs in the environment is significant regarding their impact on human health (Galdiero et al 2014 ; Jamil et al 2018 ; Krug 2022 ; Solano et al 2021 ). MONPs’ toxicity has been studied but exclusively focused on inducing cytotoxicity in living systems.…”

Section: Other Biomedical Applications Of Cuo Npsmentioning

confidence: 99%

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Naz

Gul

Zia

et al. 2023

Appl Microbiol Biotechnol

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Versatile nature of copper oxide nanoparticles (CuO NPs) has made them an imperative nanomaterial being employed in nanomedicine. Various physical, chemical, and biological methodologies are in use for the preparation of CuO NPs. The physicochemical and biological properties of CuO NPs are primarily affected by their method of fabrication; therefore, selectivity of a synthetic technique is immensely important that makes these NPs appropriate for a specific biomedical application. The deliberate use of CuO NPs in biomedicine questions their biocompatible nature. For this reason, the present review has been designed to focus on the approaches employed for the synthesis of CuO NPs; their biomedical applications highlighting antimicrobial, anticancer, and antioxidant studies; and most importantly, the in vitro and in vivo toxicity associated with these NPs. This comprehensive overview of CuO NPs is unique and novel as it emphasizes on biomedical applications of CuO NPs along with its toxicological assessments which would be useful in providing core knowledge to researchers working in these domains for planning and conducting futuristic studies. Key Points • The recent methods for fabrication of CuO nanoparticles have been discussed with emphasis on green synthesis methods for different biomedical approaches. • Antibacterial, antioxidant, anticancer, antiparasitic, antidiabetic, and antiviral properties of CuO nanoparticles have been explained. • In vitro and in vivo toxicological studies of CuO nanoparticles exploited along with their respective mechanisms. Graphical Abstract

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Section: Other Biomedical Applications Of Cuo Npsmentioning

confidence: 99%

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Naz

Gul

Zia

et al. 2023

Appl Microbiol Biotechnol

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“…Metals and metallic oxides are the materials most often employed to produce nanoparticles (NPs), whose notable physicochemical, mechanical, thermal, optical, and electrical properties sustain their application for different products for everyday use (Avramescu et al, 2020; Solano et al, 2021; Subramaniam et al, 2018; Vance et al, 2015; Yang et al, 2009). Materials on a nanometric scale (100 nm in one of its dimensions) have a greater capacity for cellular penetration and interaction with biomolecules, which intensify the direct or indirect toxicity of the NPs over biological systems (Avramescu et al, 2020; Barhoum et al, 2022; Doak et al, 2012; Parihar et al, 2018; Singh, 2018; Subramaniam et al, 2018; Yang et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…This expansion in recent years establishes new paradigms of toxicological and environmental precaution. The growing volume of these nanomaterials is destined to the environment, mainly aquatic ecosystems (Keller et al, 2013; Liu & Cohen, 2014; Parihar et al, 2018; Solano et al, 2021; Vance et al, 2015). The production chain and high consumption are associated with water pollution that has reached historical levels (Adejumoke et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Metals are a particular environmental issue because of their persistence and potential for bioconcentration and bioaccumulation up to high levels in aquatic organisms (Barhoum et al, 2022; Solano et al, 2021; Vance et al, 2015). Some characteristics of metal oxide NPs can be modified as a result of the media pH, mainly particle size and agglomeration (Avramescu et al, 2020; Bian et al, 2011; Doak et al, 2012; Jomini et al, 2012; Mitrano et al, 2015; Mudunkotuwa et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Lowering the pH leads to the disaggregation of NiO and ZnO nanoparticles and modifies the mutagenic response

Pescke,

de Oliveira Rozino,

Zenato

et al. 2023

J of Applied Toxicology

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In a changing environmental scenario, acid rain can have a significant impact on aquatic ecosystems. Acidification is known to produce corrosion in metals, hence increasing their harmful effects on the environment, organisms and human health. The prevalent use of metallic nanoparticles (NPs) in everyday products raises concerns regarding exposure and nanotoxicity even in these acidified conditions. We thus report on the cytotoxic and genotoxic potential of nickel oxide (NiO‐NP) and zinc oxide (ZnO‐NP) NPs when suspended in aqueous media in light of pH variations (7.5 and 5). A modified microsuspension method of the Salmonella/microsome assay was adopted, and strains (TA97a, TA98, TA100, TA102) were exposed to NPs (10–1280 μg/plate) with and without a metabolization fraction. The acidic condition favored disaggregation and caused a decrease in NPs size. Mutagenicity was observed in all samples and different strains, with greater DNA base pair substitution damage (TA100 and TA102), but extrinsic conditions (pH) suggest different action mechanisms of NiO‐NP and ZnO‐NP on genetic content. Mutagenic activity was found to increase upon metabolic activation (TA98, TA100, and TA102) demonstrating the bioactivity of NiO‐NP and ZnO‐NP in relation to metabolites generated by the mammalian p450 system in vitro. Modifications in the Salmonella assay methodology increased cell exposure time. The observed responses recommend this modified assay as one of the methodologies of choice for nanoecotoxicological evaluation. These findings emphasize the significance of incorporating the environmental context when evaluating the toxicity of metal‐based NPs.

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“…Inorganic nanoparticles represent an universal and essential resource with wide-ranging application relevance [1][2][3]. Many applications require non-agglomerated primary nanoparticles with a large and freely accessible surface area.…”

Section: Introductionmentioning

confidence: 99%

Fully-Automatic Benchtop Machine for the Production of Nanoparticle Suspensions

BESSEL

Barcikowski

Waag

2021

NANOCON 2021 Conference Proeedings

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Developing and exploiting applications of functional nanomaterials often require colloidal nanoparticles with defined properties. Their production suffers from batch-to-batch variability as well as poor shelf life, and distributors demand high prices. The conditions for innovative application research must be improved by easier and more robust access to colloidal nanoparticles. A compact and fully automatic benchtop machine has been developed for quick, easy and reliable production of colloidal nanoparticles. The machine uses the method of laser synthesis of colloids, converting almost any solid of choice into colloidal nanoparticles. In addition, different dispersants and stabilizers can be dosed, if desired. An almost infinite range of colloids becomes available with one machine. We provide an insight into the operation of the machine and report in particular on the high performance efficiency of the laser-based synthesis. Furthermore, we highlight the benefits of using the device in R&D of colloidal nanoparticles made possible by the technology.

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Metal- and metal/oxide-based engineered nanoparticles and nanostructures: a review on the applications, nanotoxicological effects, and risk control strategies

Cited by 37 publications

References 212 publications

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Lowering the pH leads to the disaggregation of NiO and ZnO nanoparticles and modifies the mutagenic response

Fully-Automatic Benchtop Machine for the Production of Nanoparticle Suspensions

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