Metal and Metal Oxide Nanoparticles in Caries Prevention: A Review

Nizami, Mohammed Zahedul Islam; Xu, Veena Wenqing; Yin, Iris Xiaoxue; Yu, Ollie Yiru; Chu, Chun Hung

doi:10.3390/nano11123446

Cited by 47 publications

(25 citation statements)

References 100 publications

(113 reference statements)

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“…SDF has been used worldwide for decades but was approved for dental use by the FDA in 2014 [ 27 , 28 ]. Although the exact mechanism of action has not been resolved, silver ions deposited on the dental tissues have notable antimicrobial properties [ 29 , 30 ]. Recently, silver microwires have been described in teeth treated with SDF―presumably the microwires are replacing defects that are a result of caries-provoked demineralization [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Peptide-Enabled Nanocomposites Offer Biomimetic Reconstruction of Silver Diamine Fluoride-Treated Dental Tissues

Woolfolk

Cloyd

et al. 2022

Polymers

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Caries is the most ubiquitous infectious disease of mankind, and early childhood caries (ECC) is the most prevalent chronic disease in children worldwide, with the resulting destruction of the teeth recognized as a global health crisis. Recent the United States Food and Drug Administration (FDA) approval for the use of silver diamine fluoride (SDF) in dentistry offers a safe, accessible, and inexpensive approach to arrest caries progression in children with ECC. However, discoloration, i.e., black staining, of demineralized or cavitated surfaces treated with SDF has limited its widespread use. Targeting SDF-treated tooth surfaces, we developed a biohybrid calcium phosphate nanocomposite interface building upon the self-assembly of synthetic biomimetic peptides. Here, an engineered bifunctional peptide composed of a silver binding peptide (AgBP) is covalently joined to an amelogenin derived peptide (ADP). The AgBP provides anchoring to the SDF-treated tooth tissue, while the ADP promotes rapid formation of a calcium phosphate isomorph nanocomposite mimicking the biomineralization function of the amelogenin protein. Our results demonstrate that the bifunctional peptide was effective in remineralizing the biomineral destroyed by caries on the SDF-treated tooth tissues. The proposed engineered peptide approach offers a biomimetic path for remineralization of the SDF-treated tissues producing a calcium phosphate nanocomposite interface competent to be restored using commonly available adhesive dental composites.

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Section: Introductionmentioning

confidence: 99%

Peptide-Enabled Nanocomposites Offer Biomimetic Reconstruction of Silver Diamine Fluoride-Treated Dental Tissues

Woolfolk

Cloyd

et al. 2022

Polymers

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“…They produce insoluble extracellular polysaccharides, which facilitate bacterial growth and the formation of cariogenic biofilms. This is why most of the research focuses on developing biomaterials to inhibit Streptococcus mutans [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review

et al. 2022

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Graphene is a single-layer two-dimensional carbon-based nanomaterial. It presents as a thin and strong material that has attracted many researchers’ attention. This study provides a concise review of the potential application of graphene materials in caries and periodontal disease management. Pristine or functionalized graphene and its derivatives exhibit favorable physicochemical, mechanical, and morphological properties applicable to biomedical applications. They can be activated and functionalized with metal and metal nanoparticles, polymers, and other small molecules to exhibit multi-differentiation activities, antimicrobial activities, and biocompatibility. They were investigated in preventive dentistry and regenerative dentistry. Graphene materials such as graphene oxide inhibit cariogenic microbes such as Streptococcus mutans. They also inhibit periodontal pathogens that are responsible for periodontitis and root canal infection. Graphene-fluorine promotes enamel and dentin mineralization. These materials were also broadly studied in regenerative dental research, such as dental hard and soft tissue regeneration, as well as periodontal tissue and bone regeneration. Graphene oxide-based materials, such as graphene oxide-fibroin, were reported as promising in tissue engineering for their biocompatibility, bioactivity, and ability to enhance cell proliferation properties in periodontal ligament stem cells. Laboratory research showed that graphene can be used exclusively or by incorporating it into existing dental materials. The success of laboratory studies can translate the application of graphene into clinical use.

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“…Thus, detailed studies focusing on their toxicity, bioavailability, kinetics, and biodistribution in different organs, including the liver, brain, lung, heart, and spleen, should be further investigated. Although, some studies described the potentials of copper and other metallic nanoparticles in specific or different aspects of dental applications, the biosafety was not clearly identified [ 146 , 147 , 148 ]. At the same time, the synthesis, the morphological and physicochemical properties of copper nanoparticles, and these properties’ impacts also need to be explored.…”

Section: Biocompatibility Studies Of Copper Nanoparticlesmentioning

confidence: 99%

Application of Copper Nanoparticles in Dentistry

Nizami

Yin

et al. 2022

Nanomaterials

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Nanoparticles based on metal and metallic oxides have become a novel trend for dental applications. Metal nanoparticles are commonly used in dentistry for their exclusive shape-dependent properties, including their variable nano-sizes and forms, unique distribution, and large surface-area-to-volume ratio. These properties enhance the bio-physio-chemical functionalization, antimicrobial activity, and biocompatibility of the nanoparticles. Copper is an earth-abundant inexpensive metal, and its nanoparticle synthesis is cost effective. Copper nanoparticles readily intermix and bind with other metals, ceramics, and polymers, and they exhibit physiochemical stability in the compounds. Hence, copper nanoparticles are among the commonly used metal nanoparticles in dentistry. Copper nanoparticles have been used to enhance the physical and chemical properties of various dental materials, such as dental amalgam, restorative cements, adhesives, resins, endodontic-irrigation solutions, obturation materials, dental implants, and orthodontic archwires and brackets. The objective of this review is to provide an overview of copper nanoparticles and their applications in dentistry.

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Metal and Metal Oxide Nanoparticles in Caries Prevention: A Review

Cited by 47 publications

References 100 publications

Peptide-Enabled Nanocomposites Offer Biomimetic Reconstruction of Silver Diamine Fluoride-Treated Dental Tissues

Peptide-Enabled Nanocomposites Offer Biomimetic Reconstruction of Silver Diamine Fluoride-Treated Dental Tissues

In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review

Application of Copper Nanoparticles in Dentistry

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