Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain

Ayuso-Álvarez, Ana; Núñez, Olivier; Martín-Méndez, Iván; Bel‐lan, A.; Téllez-Plaza, María; Pérez‐Gómez, Beatriz; Galán, Isolina Riaño; Fernández-Navarro, Pablo

doi:10.1016/j.envres.2021.112395

Cited by 9 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Principal component analysis (PCA) was employed to investigate the collective effects of multiple metals ( 46 ). PCA was intended to select clusters and characterized similar metals into new composite variables, called principal components (PCs).…”

Section: Methodsmentioning

confidence: 99%

An exploratory study on the association of multiple metals in serum with preeclampsia

He,

Pu,

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

BackgroundIndividual metal levels are potential risk factors for the development of preeclampsia (PE). However, understanding of relationship between multiple metals and PE remains elusive.PurposeThe purpose of this study was to explore whether eight metals [zinc (Zn), manganese (Mn), copper (Cu), nickel (Ni), lead (Pb), arsenic (As), cadmium (Cd), and mercury (Hg)] in serum had a certain relationship with PE.MethodsA study was conducted in Dongguan, China. The concentrations of metals in maternal serum were assessed using inductively coupled plasma mass spectrometry (ICP-MS). Data on various factors were collected through a face-to-face interview and hospital electronic medical records. The unconditional logistic regression model, principal component analysis (PCA) and Bayesian Kernel Machine Regression (BKMR) were applied in our study.ResultsThe logistic regression model revealed that the elevated levels of Cu, Pb, and Hg were associated with an increased risk of PE. According to PCA, principal component 1 (PC1) was predominated by Hg, Pb, Mn, Ni, Cu, and As, and PC1 was associated with an increased risk of PE, while PC2 was predominated by Cd and Zn. The results of BKMR indicated a significant positive cumulative effect of serum metals on PE risk, with Ni and Cu exhibiting a significant positive effect. Moreover, BKMR results also revealed the nonlinear effects of Ni and Cd.ConclusionThe investigation suggests a potential positive cumulative impact of serum metals on the occurrence of PE, with a particular emphasis on Cu as a potential risk factor for the onset and exacerbation of PE. These findings offer valuable insights for guiding future studies on this concern.

show abstract

Section: Methodsmentioning

confidence: 99%

An exploratory study on the association of multiple metals in serum with preeclampsia

He,

Pu,

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…The U.S. Center for Disease Control and Prevention (CDC) suggested that children’s blood lead levels should be less than 3.5 μg dL −1 ; however, more than 500,000 children in the U.S. [ 14 ] and more than 120 million people worldwide have been reported with blood lead concentrations higher than 10 μg dL −1 [ 15 ]. Recent studies regarding the long-time exposure to Pb in humans showed that it caused arterial hypertension, cardiovascular and developmental disorders, and neurological damage [ 16 , 17 ]. Therefore, lead pollution in water is a significant threat to human health.…”

Section: Introductionmentioning

confidence: 99%

Neurotoxicity of Chronic Co-Exposure of Lead and Ionic Liquid in Common Carp: Synergistic or Antagonistic?

Ding

Sultan

et al. 2022

IJMS

View full text Add to dashboard Cite

Previous studies have indicated that the harmful heavy metal lead (Pb) contamination in aquatic systems has caused intelligence development disorders and nervous system function abnormalities in juveniles due to the increased permeability of the blood–brain barrier. Ionic liquids (ILs) are considered “green” organic solvents that can replace traditional organic solvents. Studies have found the presence of ILs in soil and water due to chemical applications or unintentional leakage. Therefore, what would happen if Pb interacted with ILs in a body of water? Could ILs enable Pb to more easily cross the blood–brain barrier? Therefore, we examined the combined exposure of Pb and ILs in common carp at low concentration (18.3 mg L−1 of Pb(CH3COO)2•3 H2O and 11 mg L−1 of the IL 1-methyl-3-octylimidazolium chloride, 5% of their LC50) for 28 days in the present study. The result of a neurobehavioral assay showed that chronic exposure of lead at lower concentrations significantly altered fish movement and neurobehaviors, indicating that lead exposure caused neurotoxicity in the carp. Increases in the neurotransmitter dopamine levels and injuries in the fish brain accounted for neurobehavioral abnormalities induced by lead exposure. Moreover, we also found that lead could easily cross the blood–brain barrier and caused significant bioaccumulation in the brain. Particularly, our study indicated that the ionic liquid could not synergistically promote blood–brain barrier permeability and hence failed to increase the absorption of lead in the fish brain, suggesting that the combined exposure of lead and ILs was not a synergistic effect but antagonism to the neurotoxicity. The results of this study suggested that ILs could recede the Pb induced neurotoxicity in fish.

show abstract

Risk of heavy metal(loid) compositions in fine particulate matter on acute cardiovascular mortality: a poisson analysis in Anyang, China

Shi,

Zhi,

Zhao

et al. 2024

Int J Biometeorol

View full text Add to dashboard Cite

Metal and metalloid levels in topsoil and municipal cardiovascular mortality in Spain

Cited by 9 publications

References 44 publications

An exploratory study on the association of multiple metals in serum with preeclampsia

An exploratory study on the association of multiple metals in serum with preeclampsia

Neurotoxicity of Chronic Co-Exposure of Lead and Ionic Liquid in Common Carp: Synergistic or Antagonistic?

Risk of heavy metal(loid) compositions in fine particulate matter on acute cardiovascular mortality: a poisson analysis in Anyang, China

Contact Info

Product

Resources

About