Metal Based α-glucosidase Inhibitors: Synthesis, Characterization and α-glucosidase Inhibition Activity of Transition Metal Complexes

A review on α-glucosidase inhibitory activity of first row transition metal complexes: a futuristic strategy for treatment of type 2 diabetes

“…The inhibitory activity of L27 complexes was much higher (IC 50 = 0.9–1.20 mg mL −1 ) 75 than L26 counterparts (IC 50 = 1198–1348 mg mL −1 ). 74 …”

“…For example, 1,2diamino complexes of Pt(II) demonstrated more antitumor activity than cisplatin due to lower toxicity and drug resistance. 73 Four types of diamines including N-(n-butyl) ethylenediamine (L25), 74 1,6-diaminohexane (L26), 74 N-methylethylenediamine (L27), 75 and ethylenediamine (L28) 76 were used and the effect of the counterion (chloride, nitrate, and sulphate) was also considered in this series. As can be seen in Table 4, Cu(II) complexes of ethylenediamine (L28) possessed much higher activity than Zn(II), Ni(II), and Co(II).…”

“…Zinc(II) complexes. a-Glucosidase inhibitory activity of a series of Zn(II) complexes bearing diamines (69-77, Table 4, entries 2, 3, and 4) was studied by Tripathi et al 74,75 comparing with acarbose (IC 50 ¼ 0.14 mg mL À1 ). Among them, Zn(II) complexes of L25 showed lower activity (IC 50 ¼ 278-305 mg mL À1 ) than those of L26 (IC 50 ¼ 1.19-1.50 mg mL À1 ) and L27 (IC 50 ¼ 1.05-2.13 mg mL À1 ).…”

“…Copper(II) complexes. In the series of Cu(II) complexes (78-86, Table 4, entries 2, 3, and 5), 74,76 similar to Zn(II) complexes, complexes of L25 (77-79, IC 50 ¼ 256-279 mg mL À1 ) exhibited lower activity than those of L26 (IC 50 ¼ 1.26-1.76 mg mL À1 ) and L28 (IC 50 ¼ 0.47-0.80 mg mL À1 ). Taken together, the efficacy of ethylenediamine L28 (complexes 84-86) was more signicant than 1,6-diaminohexane L26 (complexes 81-83).…”

“…Nickel(II) complexes. Ni(II) complexes (87-95, Table 4, entries 2, 3, and 4) 74,75 were synthesized by Tripathi et al Results obtained from in vitro inhibitory studies conrmed that L25 was not desired ligand coordinated to the metal center for the induction of potent a-glucosidase inhibitory activity (IC 50 ¼ 198-226 mg mL À1 ) as compared with L26 (IC 50 ¼ 2.00-3.63 mg mL À1 ) and L27 (IC 50 ¼ 1.74-2.53 mg mL À1 ). However, comparison of complexes of L26 and L27 counterparts, indicated higher efficacy of L27 than L26.…”