Metal Binding Antimicrobial Peptides in Nanoparticle Bio-functionalization: New Heights in Drug Delivery and Therapy

Moulahoum, Hichem; Zamani, Faezeh Ghorbani; Timur, Suna; Zihnioğlu, Figen

doi:10.1007/s12602-019-09546-5

Cited by 16 publications

(8 citation statements)

References 123 publications

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“…Human histatin-1 and human serum albumin are phosphorylated on serine residues tested in this work. − However, about 20% of human histatin-1 is nonphosphorylated on Ser2. , Although phosphorylation of histatin-1 is beneficial for its binding to hydroxyapatite, this peptide plays many other roles, e.g., promotes angiogenesis and exhibits antimicrobial activity. , The involvement of phosphorylation in those processes is not known yet. The binding of metal ions by antimicrobial peptides leads to sequestration of this metal from pathogens or is necessary for other antimicrobial modes of action . Contribution of copper to maintaining microbial oral hygiene is probable as there is an inverse relationship of caries status and Cu(II) concentration in the saliva of children .…”

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confidence: 89%

“… 14 , 15 Although phosphorylation of histatin-1 is beneficial for its binding to hydroxyapatite, 16 this peptide plays many other roles, e.g., promotes angiogenesis 17 and exhibits antimicrobial activity. 3 , 18 The involvement of phosphorylation in those processes is not known yet. The binding of metal ions by antimicrobial peptides leads to sequestration of this metal from pathogens or is necessary for other antimicrobial modes of action.…”

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confidence: 99%

“…The binding of metal ions by antimicrobial peptides leads to sequestration of this metal from pathogens or is necessary for other antimicrobial modes of action. 18 Contribution of copper to maintaining microbial oral hygiene is probable as there is an inverse relationship of caries status and Cu(II) concentration in the saliva of children. 19 Overall, Ser2 phosphorylation may affect metal-related functions of histatin-1.…”

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confidence: 99%

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Phosphorylation Impacts Cu(II) Binding by ATCUN Motifs

Frączyk

2021

Inorg. Chem.

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ATCUN (amino terminal Cu(II) and Ni(II) binding) motifs chelate Cu(II) ions strongly. However, the impact of the phosphorylation of neighboring residues on such complexation has not been elucidated. The copper(II) dissociation constants of original and phosphorylated peptides from human histatin-1 and human serum albumin were compared using spectroscopic methods. Phosphorylation markedly weakened Cu(II) binding. Thus, these results indicate that phosphorylation may be a vital mechanism governing metal ion binding.

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confidence: 89%

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confidence: 99%

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Phosphorylation Impacts Cu(II) Binding by ATCUN Motifs

Frączyk

2021

Inorg. Chem.

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“…Several other studies have reported in-vivo experiments [194][195][196][197][198] reinforcing the promise of using polymer-brush HDP-conjugate design to prepare functional biomaterial surfaces. In addition to their conjugation with standard polymer brushes, peptides with antimicrobial activity have also been integrated into or with other films/surfaces, such as protein-based films (i.e., self-assembled protein nanostructures) [199][200][201][202][203][204][205][206], silk surgical sutures [207,208], metal nanoparticles [209,210] and other solid interfaces, in order to provide biomaterials that can prevent and minimize the risks of bacterial infections.…”

Section: Surface Engineered Polymeric-brush-tethered Hdpsmentioning

confidence: 99%

Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success

Etayash

Hancock

2021

Pharmaceutics

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Amphiphilic antimicrobial polymers have attracted considerable interest as structural mimics of host defense peptides (HDPs) that provide a broad spectrum of activity and do not induce bacterial-drug resistance. Likewise, surface engineered polymeric-brush-tethered HDP is considered a promising coating strategy that prevents infections and endows implantable materials and medical devices with antifouling and antibacterial properties. While each strategy takes a different approach, both aim to circumvent limitations of HDPs, enhance physicochemical properties, therapeutic performance, and enable solutions to unmet therapeutic needs. In this review, we discuss the recent advances in each approach, spotlight the fundamental principles, describe current developments with examples, discuss benefits and limitations, and highlight potential success. The review intends to summarize our knowledge in this research area and stimulate further work on antimicrobial polymers and functionalized polymeric biomaterials as strategies to fight infectious diseases.

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“…The proteins and peptides possessing the ATCUN (amino-terminal copper and nickel) motif are considered to be physiological Cu( ii ) carriers. 5,6 The ATCUN sequence consists of the His3 residue preceded by any two amino acid residues, except Pro2, and possesses a free amine group at the N-terminus. In the physiological pH range its Cu( ii ) complex is square planar, with a four-nitrogen (4N) coordination mode (Fig.…”

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confidence: 99%