Metal-Catalyzed Routes for the Synthesis of Furocoumarins and Coumestans

Cadierno, Victorio

doi:10.1016/b978-0-12-800070-0.00004-9

Cited by 5 publications

(11 citation statements)

References 165 publications

(115 reference statements)

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“…The synthesis of furocoumarins has been known for a long time. However, novel methodologies have been developed during the last decades for the effective preparation of these compounds, many of which involve metal-catalyzed transformations that provide new structural diversity [ 80 , 81 ].…”

Section: Coumarin Derivatives From Marine World: Synthesis and Activi...mentioning

confidence: 99%

Recent Advances in Biologically Active Coumarins from Marine Sources: Synthesis and Evaluation

2022

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Coumarin and its derivatives have significantly attracted the attention of medicinal chemists and chemical biologists due to their huge range of biological, and in particular, pharmacological properties. Interesting families of coumarins have been found from marine sources, which has accelerated the drug discovery process by inspiring innovation or even by the identification of analogues with remarkable biological properties. The purpose of this review is to showcase the most interesting marine-derived coumarins from a medicinal chemistry point of view, as well as the novel and useful synthetic routes described to date to achieve these chemical structures. The references that compose this overview were collected from PubMed, Mendeley and SciFinder.

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Section: Coumarin Derivatives From Marine World: Synthesis and Activi...mentioning

confidence: 99%

Recent Advances in Biologically Active Coumarins from Marine Sources: Synthesis and Evaluation

2022

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“…Furobenzopyrone (or furocoumarins) comprises an important class of coumarins found in a wide variety of plants, particularly in the carrot ( Apiaceae/Umbelliferae ), legume ( Fabaceae ), and citrus families ( Rutaceae ) [ 27 ]. The chemical structure of furobenzopyrone (furocoumarins) consists of a furan ring fused with coumarin.…”

Section: Synthesis Of Benzopyrone-fused Five-membered Aromatic Hementioning

confidence: 99%

“…To date, different transition metal (Au, Pt, and Cu) catalyzed/mediated methodologies for benzopyrane synthesis have been reported [ 27 , 42 , 45 , 46 ]. Cheng and Hu described a one-pot cascade of an addition/cyclization/oxidation sequence using CuCl 2 as the oxidant and CH 3 SO 3 H as the acid for regioselective synthesis of 2-substituted-4 H -furo[3,2- c ]benzopyran-4-ones 22 from the substituted 3-alkynyl-4 H -benzopyran-4-one 20 ( Scheme 7 ) [ 47 ].…”

Section: Synthesis Of Benzopyrone-fused Five-membered Aromatic Hementioning

confidence: 99%

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Synthetic Routes to Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles Built on the α-Pyrone Moiety. Part 1: Five-Membered Aromatic Rings with One Heteroatom

El‐Sawy

Abdelwahab²,

Kirsch

2021

Molecules

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“…Additional natural compounds other than bioflavonoids may also act as inhibitors of Top2. Bakuchicin from the furanocoumarin family is present in fruits and legumes [74]. In research conducted to study DNA-polymerase inhibition activity of Psoralea corylifolia L. (Leguminosae), bakuchincin was found to be a weak Top2 inhibitor [75].…”

Section: Additional Compounds As Top2 Inhibitorsmentioning

confidence: 99%

DNA Damage and Repair Mechanisms Triggered by Exposure to Bioflavonoids and Natural Compounds

Goodenow¹,

Lalwani²,

Richardson³

2021

DNA - Damages and Repair Mechanisms

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Eukaryotic cells use homologous recombination (HR), classical end-joining (C-NHEJ), and alternative end-joining (Alt-EJ) to repair DNA double-strand breaks (DSBs). Repair pathway choice is controlled by the activation and activity of pathways specific proteins in eukaryotes. Activity may be regulated by cell cycle stage, tissue type, and differentiation status. Bioflavonoids and other environmental agents such as pesticides have been shown to biochemically act as inhibitors of topoisomerase II (Top2). In cells, bioflavonoids directly lead to DNA double-strand breaks through both Top2-dependent and independent mechanisms, as well as induce DNA damage response (DDR) signaling, and promote alternative end-joining and chromosome alterations. This chapter will present differences in expression and activity of proteins in major DNA repair pathways, findings of Top2 inhibition by bioflavonoids and cellular response, discuss how these compounds trigger alternative end-joining, and conclude with implications for genome instability and human disease.

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Metal-Catalyzed Routes for the Synthesis of Furocoumarins and Coumestans

Cited by 5 publications

References 165 publications

Recent Advances in Biologically Active Coumarins from Marine Sources: Synthesis and Evaluation

Recent Advances in Biologically Active Coumarins from Marine Sources: Synthesis and Evaluation

Synthetic Routes to Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles Built on the α-Pyrone Moiety. Part 1: Five-Membered Aromatic Rings with One Heteroatom

DNA Damage and Repair Mechanisms Triggered by Exposure to Bioflavonoids and Natural Compounds

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