Metal Chelates of Tridentate (NNO) 1,2,4-Triazine Schiff Base: Synthesis, Physico-chemical Investigation and Pharmacological Screening

Dharsini, G.R. Priya; Thanaraj, Clarina; Rama, Velladurai

doi:10.1007/s10904-019-01413-8

Cited by 13 publications

(6 citation statements)

References 19 publications

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“…Upon coordination with the metals, the polarity gets reduced because of the overlap of ligand orbitals and the partial distribution of the positive charge of the metal ion. The process of coordination enhances the delocalization of pi‐electrons over the chelate thereby increasing the lipophilicity and hydrophobicity of the complexes, which provides the assess for the metal complexes across the microbial cell membranes 17,44,45 …”

Section: Resultsmentioning

confidence: 99%

“…The process of coordination enhances the delocalization of pi-electrons over the chelate thereby increasing the lipophilicity and hydrophobicity of the complexes, which provides the assess for the metal complexes across the microbial cell membranes. 17,44,45 3.4 | Antioxidant activity…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…16 Recently, Dharsini et al focused on the triazine-lawsone complexes and their pharmacological aspects. 17 From all these, we come to know that only one article is based on the biological evaluation of the metal complexes of lawsone Schiff bases and no article has focused on the computational evaluation of the biological properties of such lawsone Schiff bases. This shows that further more investigation on the biological assessment of much bioactive lawsone-based Schiff bases and their metal complexes is needed.…”

Section: Introductionmentioning

confidence: 99%

“…Copper chelates of thiosemicarbazone–lawsone Schiff base ligands were prepared by Chikate et al and analysed for EPR and redox studies 16 . Recently, Dharsini et al focused on the triazine‐lawsone complexes and their pharmacological aspects 17 . From all these, we come to know that only one article is based on the biological evaluation of the metal complexes of lawsone Schiff bases and no article has focused on the computational evaluation of the biological properties of such lawsone Schiff bases.…”

Section: Introductionmentioning

confidence: 99%

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New homoleptic imine derivative of lawsone and its metal complexes: Preparation, characterization, in vitro and in silico biological investigation

Sheela,

Kumar,

Raman

2023

Applied Organom Chemis

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In this article, a Schiff base derivative has been prepared using 2‐hydroxy‐1,4‐naphthoquinone and 3‐amino‐1,2,4‐triazole, and consecutively, four metal complexes (Co(II), Ni(II), Cu(II) and Zn(II)) have been synthesized using this Schiff base derivative as precursor ligand. Characterization of the synthesized compounds are done by employing spectral techniques such as UV–vis, infrared (IR), nuclear magnetic resonance (NMR), mass and electron paramagnetic resonance (EPR). All these methods establish the existence of imine group and the octahedral geometry of the complexes. The synthesized complexes are evaluated for their DNA binding properties that confirm that the binding mode is intercalation. The bioactive ligand and its complexes also exhibit pronounced pharmacological activities such as antioxidant and antimicrobial activities against bacteria such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella typhi; fungi, namely, Aspergillus niger, Aspergillus flavus, Candida albicans and Rhizoctonia bataticola. Moreover, the compounds are examined for their density functional theory (DFT) studies using Gaussian 09 programme. Various reactivity descriptors are calculated based on the highest occupied molecular orbital–lowest unoccupied molecular orbital (HOMO‐LUMO) energies. Molecular docking is conducted with two different receptors 1BNA and 1HD2 proteins to get a wide knowledge on the in vitro biological examination and also the interaction of the compounds with different proteins.

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Section: Resultsmentioning

confidence: 99%

Section: Antimicrobial Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

New homoleptic imine derivative of lawsone and its metal complexes: Preparation, characterization, in vitro and in silico biological investigation

Sheela,

Kumar,

Raman

2023

Applied Organom Chemis

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“…made them a topic of increasing interest in the current research scenario. During recent years, investigations on Schiff bases possessing N, S, O heterocycles like 1,2,4-triazines became a hot spot in the research arena [ 2 , 3 , 4 , 5 ]. It was suggested that the azomethine linkage, as well as additional donor sites in 1,2,4-triazine moieties, make them more versatile and flexible with biological, pharmacological, and medicinal properties [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, in silico, and in vitro biological screening of coordination compounds with 1,2,4-triazine based biocompatible ligands and selected 3d-metal ions

P¹,

Prasad

Joseph

2020

Heliyon

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A bidentate Schiff base ligand, MHMMT, obtained from 1,2,4-triazine derivative and 4-hydroxy-3-methoxy benzaldehyde and its Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesised in ethanolic media and characterized by various analytical techniques like elemental analyses, magnetic susceptibility measurements, FTIR, UV-VIS, proton NMR, ESR, spectroscopic and thermogravimetric studies. Various geometries like a tetrahedral for Co(II) and Zn(II) complexes, an octahedral for Fe(III) and Ni(II) complexes, and square planar for Cu(II) complex has been assigned. For all metals complexes except Co(II), a 2:1 ligand to metal ratio is observed, while Co(II) complex has a 1:1 ratio. In accordance with the probable activity spectra of substances as obtained from PASS analysis, in vitro α-amylase inhibition studies by starch-iodine method for ligand and complexes except that of Fe(III) and anticancer screening against human breast cancer cell lines MCF-7 using MTT assay for Fe(III) complex were conducted. The tested compounds were found to be good α-amylase inhibitors, characteristically similar to most of the antidiabetic drugs. Among the compounds, Cu(II) complex exhibited the highest α-amylase inhibitory activity. Furthermore, ligand and complexes were also exposed to in vitro antimicrobial activities, drug-likeness, bioactivity score prediction by Molinspiration software. Molecular docking analysis of selected compounds on α-amylase and VEGFR-2 kinase were carried out for confirming the experimental observations.

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Synthesis, Characterization, DFT Studies and Biological Activity of Ru(III), La(III) and Ce(III) Triphenylphosphine Complexes Containing 2-Aminothiazole and 2-Aminotriazole

Naik

Krishnamurthy

et al. 2020

J Inorg Organomet Polym

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Metal Chelates of Tridentate (NNO) 1,2,4-Triazine Schiff Base: Synthesis, Physico-chemical Investigation and Pharmacological Screening

Cited by 13 publications

References 19 publications

New homoleptic imine derivative of lawsone and its metal complexes: Preparation, characterization, in vitro and in silico biological investigation

New homoleptic imine derivative of lawsone and its metal complexes: Preparation, characterization, in vitro and in silico biological investigation

Synthesis, characterization, in silico, and in vitro biological screening of coordination compounds with 1,2,4-triazine based biocompatible ligands and selected 3d-metal ions

Synthesis, Characterization, DFT Studies and Biological Activity of Ru(III), La(III) and Ce(III) Triphenylphosphine Complexes Containing 2-Aminothiazole and 2-Aminotriazole

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