Metal Complex Catalysis in the Synthesis of Spirocarbocycles

Ionic [Ru] complex with recyclability by electro-adsorption for efficient catalytic transfer hydrogenation of aryl ketones

“…Organometallics are widely used as reagents or catalysts in organic synthesis [1][2][3] . The use of organometallics allows for the cleavage and recombination of various chemical bonds, especially in the catalysis of organic transformation, such as reduction of olefi n, carbonyl, and imine 4-6 , the oxidation of alcohol and aldehyde 7- 8 , and activation of C-H bond and small inert molecule, such as nitrogen 9-10 .…”

Hybrid macrocycle formation and spiro annulation on cis-syn-cis-tricyclo[6.3.0.02,6]undeca-3,11-dione and its congeners via ring-closing metathesis

“…In this context, new synthetic methods to generate multiple spirocenters in a simple manner remain a challenging task. Although, a variety of strategies have been investigated, a limited number of general methods are available [ 33 – 46 ] for the generation of multiple spirocenters in a single step [ 43 ]. To expand the chemical space of aza-polyquinanes we conceived a new strategy based on Fischer indolization and ring-closing metathesis as the key steps.…”

Highly Efficient Cascade Reaction for Selective Formation of Spirocyclobutenes from Dienallenes via Palladium-Catalyzed Oxidative Double Carbocyclization–Carbonylation–Alkynylation

“…1,2 These structural elements occur in a wide range of natural products, pharmaceutical ingredients, and chiral ligands. 3,4 Therefore, chemists have devoted themselves to developing new strategies for addressing the challenges involving spirocarbocycles.…”

“…3,4 Therefore, chemists have devoted themselves to developing new strategies for addressing the challenges involving spirocarbocycles. 1 To date, different methods have been developed to construct this core motif, such as N -heterocyclic carbene-based organocatalysis, 5 metal-catalyzed dearomatization reaction, 6 and alkene metathesis with Grubbs catalysts. 7 However, development of methodologies for the fast and efficient construction of spirocarbocycles are still highly desirable and challenging.…”