Metal complexes derived from hydrazoneoxime ligands VI. Synthesis, characterization and structures of zinc(II) complexes derived from aroylhydrazoneoximes

A new series of dihydrazone-oxime ligand's homo-bimetallic complexes of for-butan-2-ylidene)hydrazono)indolin-2-one (HL,1) with the salts of Fe 3+ , Ru 3+ , Co 2+ , Cu 2+ , Mn 2+ , Zn 2+ , and UO 2 2+. The newly prepared compounds' structure was elucidated based on traditional techniques such as molar conductance, magnetic measurements, elemental, thermogravimetric (TGA) analyses, and mass spectrometry, as well as spectroscopic tools such as electronic absorption, infrared, nuclear magnetic resonance, mass, and electron spin resonance spectra. The values of complexes molar conductance in DMSO indicated that they

Section: Nmr Spectrummentioning

confidence: 99%

mentioning

confidence: 99%

New homo‐bimetallic complexes of dihydrazone‐oxime ligand incorporating isatinic moiety: Preparation, characterization, theoretical, microbicidal, and anticancer investigation

Ebrahium

2023

“…[37] Many scientists have recently investigated the preparation and characterization of metallic complexes with hydrazone or hydrazone-oxime chelators, as well as their biological activities. [2,3,38,39] The current study devoted to the preparation of Cu 2+ , Ni 2+ , Mn 2+ , Co 2+ , and Zn 2+ complexes of dihydrazone-oxime incorporating isatinic moiety, namely, 3-((3-(hydroxyimino)butan-2-ylidene)hydrazono) indolin-2-one (HL,1). The molecular structure of these designated compounds was investigated by NMR, electronic absorption, infrared, and mass spectra as well as elemental, thermal, and theoretical tools.…”

Section: Introductionmentioning

confidence: 99%

Monometallic complexes of novel dihydrazone‐oxime ligand: Synthesis, structure, spectral, DFT, and in vitro bioactivity investigation against fungal, bacterial, and tumor cells

Ebrahium

2023

In the current study, uni‐metallic Cu2+, Ni2+, Mn2+, Co2+, and Zn2+ complexes of ONN‐tridentate dihydrazone‐oxime incorporating indolin‐2‐one moiety (HL,1) were synthesized and structurally characterized employing elemental, spectral, thermo‐gravimetric, magnetic, and molar conductivity measurements, to investigate the structure and composition of these new uni‐metallic complexes. According to the results of several analyses, the dihydrazone‐oxime behaved as a mono‐negative or neutral tridentate ONN chelator bound the metal cations in molar ratio (1M:1L) through the isatinic carbonylic oxygen, azomethine nitrogen, and nitrogen atom of deprotonated/protonated oximatic moiety forming uni‐metallic complexes with formulae [M(L)XYZ(H2O)].nH2O (where M = Cu2+ (2–4), Ni2+, Mn2+, Co2+, or Zn2+, X = Cl, CH3COO, or NO3, Y = H2O or 0, Z = H2O or 0, n = 2, 0) and [Cu (HL)(SO4)(H2O)]. The Cu2+ complexes were found to have a tetragonally distorted octahedral or square pyramidal geometry, whereas those of Mn2+, and Ni2+, exhibited a tetrahedral geometry but Co2+ complex demonstrated a distorted octahedral geometry. Based on DFT‐B3LYP technique and 6‐311G++(d,p) basis set, The DFT data confirmed the structural investigation of dihydrazone‐oxime and its complexes, revealing that the complexes reactivity is more than un‐complexed dihydrazone‐oxime. Moreover, quantum chemical parameters of dihydrazone‐oxime and its uni‐metallic complexes like the energies of both lowest unoccupied molecular orbital (ELUMO) and highest occupied molecular orbital (EHOMO), separation energy (ΔE = ELUMO − EHOMO), chemical potential, absolute electronegativity, absolute hardness, and absolute softness were obtained. According to the thermogravimetric analysis, the complexes breakdown in two to four disintegrating phases in range of temperature 25°C to 575°C leaving the oxide of metal or metal oxide contaminated with carbon. In vitro microbicide effect of the un‐complexed dihydrazone‐oxime and its uni‐metallic complexes toward various bacterial and fungal strains was tested by agar‐well diffusion method. It is demonstrated that the complexes are more effective than free dihydrazone‐oxime. The antitumor activity has been also analyzed against three cell lines including prostate adenocarcinoma (PC‐3), ovarian adenocarcinoma (SKOV3), and cervical cancer (HeLa) cell lines. Studies showed that all complexes have greater inhibition activity against the above three cell lines than the free dihydrazone oxime and the most effective compound was the Zn2+ complex (9) with IC50, 27.42, 35.16, and 46.77 μg/ml, respectively.

Synthesis, structure, and catalytic performance of solvent induced zinc clusters in furan synthesis by cycloisomerization reaction

Farzaneh‐Bonab,

Bikas,

Noshiranzadeh

et al. 2024

Two Zn(II) clusters were synthesized by the reaction of Zn(OAc)2·2H2O and 1,2‐bis(2‐hydroxy‐3‐methoxybenzylidene)hydrazine as a N2O4‐donor Schiff base ligand in 1:3 molar ratio. The reaction in methanol gave yellow‐brown needle crystals, while block yellow crystals were achieved in a mixture of methanol:water (50:50 v/v). Investigation of the crystals by single crystal X‐ray analysis showed that solvent has considerable effect on the structure and composition of the products. In methanol, two independent pentanuclear Zn(II) clusters with the same general formula of [Zn5(L)2(μ‐OAc)4(OAc)2(CH3OH)2] but different coordination environments around Zn(II) cores, and bridging mode of the acetate ligands are present in the unit cell. In a mixture of methanol:water, a pentanuclear cluster and a 1D coordination polymer with pentanuclear repetitive unit are simultaneously present in the crystal structure. These compounds were further characterized by spectroscopic techniques, and they were used as catalysts for intramolecular cycloisomerization of 1,4‐diphenylbut‐3‐yn‐1‐one. The results indicated that these Zn(II) clusters can efficiently produce 2,5‐diphenylfuran through catalytic cycloisomerization reaction.