N-(4-acetylphenyl)maleimide. The structure of monomer, homopolymer and copolymer, metal composites were elucidated by FT-IR, 1 H-NMR and elemental analysis. The nine copolymer samples were synthesized from different feed ratio of comonomer. The monomer reactivity ratio r NAPMI and r AA were determined by Finemann Ross method. The investigated homo and copolymers showed solubility in polar solvents. Thermal behavior of homopolymer and copolymer were evaluated by TGA and DSC.The molecular weights were determined by GPC. The antimicrobial activity of synthesized homopolymer, copolymer and were screen against various bacteria and fungi and they showed excellent antimicrobial activity.