Metal complexes of moxifloxacin–imidazole mixed ligands: Characterization and biological studies

Soayed, Amina A.; Refaat, Heba M.; El-Din, Doaa A. Noor

doi:10.1016/j.ica.2013.04.040

Cited by 44 publications

(38 citation statements)

References 70 publications

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“…Amina et al have reported metal complexes of moxifloxacin-imidazole mixed ligands: characterization and biological studies. The majority of researchers reported about the preparation and characterization of the moxifloxacin-metal complexes with transition metals and studied their biological applications (Nakamoto et al 1968;Soayed et al 2013;Sultana et al 2014).…”

mentioning

confidence: 99%

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

Seku¹,

Yamala

Kancherla³

et al. 2018

J Anal Sci Technol

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Methods: Moxifloxacin-Au(III) and Ag(I) metal complexes were prepared by adding corresponding aqueous solutions of Au(III) and Ag(I) metal salts to methanolic solution of Moxifloxacin. These metal complexes were characterized by physio-chemical techniques like UV-Vis, 1 H-NMR, FTIR, XRD, DSC, TGA, SEM and microanalytical data. The disc diffusion method was used to study the antibacterial activity of the Moxifloxacin-metal complexes.

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mentioning

confidence: 99%

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

Seku¹,

Yamala

Kancherla³

et al. 2018

J Anal Sci Technol

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“…Absorption bands attributed to carboxyl group v(C=O) carb can be found both in the complex spectrum (1708 cm -1 ) and in the one of OFL (1712 cm -1 ) without noticeable changes in [24,[28][29][30]. The stretching vibration for the pyridone group v(C=O) py mentioned in the literature are assigned to 1621 cm -1 (moxifloxacin) and 1630 cm -1 (norfloxacin) [11,29]. The stretching vibration for the pyridone group v(C=O) py are identical for both the OFL and the complex obtained at 1621 cm -1 [13].…”

Section: Ft-ir Spectroscopy Analysismentioning

confidence: 80%

“…This complexation presents a particular coordination with the quinolone as the monodentate ligand through the N4'-piperazine atom or possibly through a complex polymeric form, different from most other metal complexes of quinolone antibacterials. Although the silver bactericide potential is known from ancient times, only a few studies have used this metal ion to obtain quinolone antibacterial metal complexes [1,11].…”

Section: Introductionmentioning

confidence: 99%

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A New Silver Complex with Ofloxacin – Preliminary Study

Rusu

Popescu

Imre

et al. 2016

Acta Medica Marisiensis

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Objective: Silver complexes of antibacterial quinolones have the potential advantage of combining the antibacterial activity of silver and fluoroquinolones. The objective of our study was the preparation and the preliminary physico-chemical characterization of a silver complex with ofloxacin. Methods: To achieve our goals several spectroscopic methods (ultraviolet spectrophotometry, mass spectrometry, and Fourier transform infrared spectroscopy) and thermal methods (differential scanning calorimetry and thermogravimetric analysis) were used in order to elucidate the chemical structure of the complex. Results: Using mass spectrometry we established the stoichiometric ratio silver:ofloxacin as 1:2. Experimental data suggest a particular coordination for ofloxacin, as a monodentate ligand, in the formation of a complex with silver, through the nitrogen atom from the methyl-piperazine cycle. IntroductionDue to the excellent chelating properties of quinolone antibacterial several metal complexes of these substances were synthesized and studied for their possible antibacterial and antifungal activities. The silver ion is known for its antibacterial and antifungal properties. Fluoroquinolones are synthetic antibacterial agents, with broad spectrum activity, good oral absorption and bioavailability. The 4-oxo and 3-carboxyl groups of fluoroquinolones offer excellent chelating properties for metal ions. Silver complexes of fluoroquinolone antibacterial have the advantage of combining the antibacterial activity of the silver ion with the one of the fluoroquinolone. There are a large number of studies on the complexation of antibacterial fluoroquinolones with metal ions using different metals [1]. Metal complexes have been synthesized with antimicrobial activity equal to or greater with the corresponding quinolone antibacterial. Research on the fluoroquinolone metal complexes has revealed also other biological effects: antifungal, antiparasitic, anticancer, anti-inflammatory, antioxidant and even insulin mimetic [2][3][4]. In the category of metal complexes with promising therapeutic effects are included those containing silver [5][6][7][8][9][10].Complexation of antibacterial quinolones with silver combines the antibacterial activity of Ag (I) with the one of the quinolone. This complexation presents a particular coordination with the quinolone as the monodentate ligand

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“…Compared with complex 1, the stretching vibration peak of the C=O bonds in complex 3 moves to high wavenumber, which can illustrate that both the oxygen atoms in biuret molecules and acetate anions are coordinated to the manganese ions in complex 3. The absorption peaks at 476 cm −1 in complexes 1 and 2 are originated to the stretching vibrations of the Ni−O bonds, and the absorption peaks at 459 cm −1 in complexes 3 and 4 are the characteristic peaks of the Mn−O bonds [13][14][15][16][17]. Figures 5 and 6 show the Raman spectra of the complexes obtained in the 400−4000 cm −1 range, and the frequencies data of the biuret and its complexes are listed in Table 3.…”

Section: Ir Spectroscopy Analysismentioning

confidence: 99%

Synthesis, Optical Characterization, and Thermal Decomposition of Complexes Based on Biuret Ligand

Wang

Chen

2016

International Journal of Optics

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Four complexes were synthesized in methanol solution using nickel acetate or nickel chloride, manganese acetate, manganese chloride, and biuret as raw materials. The complexes were characterized by elemental analyses, UV, FTIR, Raman spectra, Xray powder diffraction, and thermogravimetric analysis. The compositions of the complexes were, and [Mn(bi) 2 Cl 2 ] (4) (bi = NH 2 CONHCONH 2 ), respectively. In the complexes, every metal ion was coordinated by oxygen atoms or chlorine ions and even both. The nickel and manganese ions were all hexacoordinated. The thermal decomposition processes of the complexes under air included the loss of water molecule, the pyrolysis of ligands, and the decomposition of inorganic salts, and the final residues were nickel oxide and manganese oxide, respectively.

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Metal complexes of moxifloxacin–imidazole mixed ligands: Characterization and biological studies

Cited by 44 publications

References 70 publications

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

A New Silver Complex with Ofloxacin – Preliminary Study

Synthesis, Optical Characterization, and Thermal Decomposition of Complexes Based on Biuret Ligand

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