Metal Complexes of Oxadiazole Ligands: An Overview

Abstract

Oxadizoles are heterocyclic ring systems that find application in different scientific disciplines, from medicinal chemistry to optoelectronics. Coordination with metals (especially the transition ones) proved to enhance the intrinsic characteristics of these organic ligands and many metal complexes of oxadiazoles showed attractive characteristics for different research fields. In this review, we provide a general overview on different metal complexes and polymers containing oxadiazole moieties, reporting the principal synthetic approaches adopted for their preparation and showing the variety of applications they found in the last 40 years.

Crystal structure of poly[(μ3-4-amino-1,2,5-oxadiazole-3-hydroxamato)thallium(I)]

“…2). The Tl-O bond lengths involving the hydroxamate oxygen atoms in 1 are typical for Tl I compounds (Salassa & Terenzi, 2019), and the formation of similar polymeric chains is frequently observed for Tl I complexes (Akhbari et al, 2009). The resulting coordination sphere of Tl1 can be best described as a distorted seesaw (SS-4) or disphenoid with a stereochemically active lone pair (Mudring & Rieger, 2005).…”

Coordination Polymers Based on Highly Emissive Ligands: Synthesis and Functional Properties

“…1,3,4-Oxadiazoles are well-known for their range of biological activities [101], but also they along with their coordination compounds are extensively used in highly emissive materials [102,103]. [104].…”

Ammonium Formate-Pd/C as a New Reducing System for 1,2,4-Oxadiazoles. Synthesis of Guanidine Derivatives and Reductive Rearrangement to Quinazolin-4-Ones with Potential Anti-Diabetic Activity

“…The use of a 1,2,4-oxadiazole ring as an isosteric replacement of esters and amides increased their presence in medicinal chemistry projects [2] with biological applications ranging from the treatment of nonsense mutations [3,4] and Alzheimer's disease (AD) [5][6][7] to antibiotics [8][9][10] and antitumorals [11,12]. Applications in the field of materials chemistry, such as liquid crystals [13] metal sensors [14], OLED [15], energetic materials [16] and gas sorbing/releasing systems [17][18][19], have been reported. The high tendency to react and rearrange of this low-aromatic ring is one of the features that is mainly related to O-N bond breaking [20].…”