Metal complexes of Proline-Azo Dyes, Synthesis, Characterization, Dying Performance and Antibacterial Activity Studies

Abbas, Alya Khider; Kadhim, Rafal Salam

doi:10.13005/ojc/330148

Cited by 10 publications

(9 citation statements)

References 5 publications

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“…The spectra revealed signals and peaks corresponding to the functional groups present in some of the synthesized compounds listed in Tables 1 and 2. [48][49][50] Some of the synthesized compounds were screened for their biological activities against both different type of bacteria E. Coli and Staphylococcus aureus and against fungal Candida albicans using their three concentrations in DMSO as solvent, the inhibition zones for these compounds are inserted in Tables 3 and Tables…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of some new heterocyclic derivatives from aromatic carbonyl ‎compounds and carboxylic acids with Evaluation some of them for biological activity

Al-Khazraji,

Ahamed,

Ali

2024

Iraqi Journal of Science

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In this research investigation, a total of eighteen diverse tetra- and penta-lateral cyclic compounds were synthesized. These included 1,3,4-thiadiazole, thiazolidin-4-one (via an alternative method), 1,2,4-triazole, carbothioamide, thiazole-4-one, azetidin-2-one, and oxazole. The synthesis procedure entailed a sequence of reactions. The thiazolidine-4-one 1 was obtained by reaction p-aminobenzoic acid with thiosemicarbazide, followed by treatment with p-tolualdehyde to produce Schiff base 2. Reaction Schiff base 2 with mercaptoacetic acid in dry benzene was carried out to produce thiazolidine-4-one 3. In another synthesis pathway, the esterification of p-nitro benzoic acid with ethanol in the presence of sulfuric acid was obtained to formation of compound 4. Compound 4 was subsequently reacted with thiosemicarbazide, yielding compound 5. Cyclization of compound 5 was then achieved using 4% sodium hydroxide solution. This formed the 1,2,4-triazole heterocycle, designated compound 6. Thiosemicarbazone 7-9 were prepared by reaction of thiosemicarbazide with different aldehydes. Additionally, 2-substituted-1,3-thiazolidine-4-one derivatives 10-12 were synthesized through the reaction of thiosemicarbazone with chloroacetic acid in the presence of anhydrous sodium acetate. The Oxazole derivative 15 was obtained through a series of reactions starting with the reaction of p-amino benzoic acid with ethyl chloroacetate, resulting in compound 13. Compound 13 was then treated with urea to obtain compound 14, followed by a reaction with 4-phenyl phenacyl bromide to yield the final product, the Oxazole derivative 15. The 2-aminooxadiazole derivative 16 was synthesized by reaction urea with 4-bromoacetophenone which was reacted with 4-bromobenzaldehyde to produce Schiff base derivative 17. Finally, β-lactam 18 is obtained through reaction Schiff base with chloroacetyl chloride in the presence of triethyl amine. FT-IR, 1H-NMR, and 13C-NMR spectroscopy were used to confirm their proposed structures. Moreover, the antibacterial and antifungal activities of certain synthesized compounds, specifically 2,3,6,11,13,15,17, and 18, were assessed against Staphylococcus aureus, Escherichia coli, and Candida albicans, demonstrating encouraging outcomes.Keywords: Antibacterial, antifungal activity, oxadaizole, heterocyclic derivatives, Oxazole.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of some new heterocyclic derivatives from aromatic carbonyl ‎compounds and carboxylic acids with Evaluation some of them for biological activity

Al-Khazraji,

Ahamed,

Ali

2024

Iraqi Journal of Science

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“…By measuring at a 575 nm wavelength using an ELISA reader. To calculate the concentration of chemicals needed to reduce cell viability by 50% for each cell line, optical density data were submitted to statistical analysis [16].…”

Section: Anticancer Effectivenessmentioning

confidence: 99%

Metal Complexes of Adenine Azo Ligand: Synthesis, Identification and Study some of their Applications

Abd,

Abbas

2024

Iraqi Journal of Science

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This scientific paper presents two novel lanthanide metal complexes [Sm (III) and Ce (IV)] synthesized through a series of reactions involving organic ligand 8-[3-(pyrazoyl)azo]adenine (PAA). Ligand (PAA) and their complexes were characterized using various analytical techniques, including C.H.N.S elemental analysis, magnetic measurement, X-ray diffraction, thermal analysis, SEM, (TGA) UV-Vis spectroscopy, FT-IR spectroscopy, and HNMR analysis. These techniques were employed to support the mode of binding and geometrical structure for ligand (PAA) and its Lanthanide (Ln) complexes. The FTIR and HNMR spectral results showed that (PAA) acts as neutral N,N-bidentate with [Sm (III) and Ce (IV)]. The geometric shape of the synthesized Ln-complexes is octahedral. Also, TGA was used to investigate the thermal behavior of ligand and its complex. The results showed that the ligand dissociated in three steps, while the complex dissociated in five steps. This indicates that the complex is more thermally stable than the ligand, likely due to the formation of strong coordination bonds between the ligand and the metal ions. These findings can contribute to the understanding of the thermal stability of metal complexes and inform the design of new metal-based materials with desirable properties. Finally, this paper examined the antibacterial, antifungal and anticancer activities of PAA and its complexes. The results indicated that all of these compounds exhibited significant activity against bacterial and fungal pathogens, as well as cancer cells.

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“…This group consists of also two nitrogen atoms linked directly together (-N=N-) [17][18][19]. As a result, the formed complex involves a linkage between the metal ion with the azo group, the imidazole nitrogen atom and even other available groups or atoms suitable for coordination in the ligand chemical structure to form the stable chelate ring [20][21][22]. The resulted complex containing imidazole and azo group as a coordinating ligand is well known for its significant biological and industrial importance [23,24].…”

Section: Introductionmentioning

confidence: 99%

Co(II) and Ni(II) complexes with bis(4-((E)-(4,5-diphenyl-1H-imidazol-2-yl)diazenyl) phenyl)methane: synthesis, characterization and anti-corrosion effect investigation

Taha Saad

2024

Bull. Chem. Soc. Eth.

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Bright coloured Co (II) and Ni (II) complexes of an azo ligand were synthesized. This ligand was previously synthesized from the coupling reaction between 4,5-diphenyl imidazole and 4,4-diaminodiphenylmethane in 1:2 molar ratio (4,4-diaminodiphenylmethane and 4,5-diphenyl imidazole). The synthesis process of the complexes involved the reflux reaction between the azo ligand with both metal salts. The synthesized complexes were characterized by FTIR, UV.-Visible, molar conductivity and atomic absorption. From the obtained characteristic data of the FTIR spectra, the coordination between the two metals and the azo ligand occurs by the coordination with the nitrogen atom of the azo group and one of the nitrogen atoms in the imidazole both rings. The molar conductivity test confirm the non- electrolytic nature of both complexes, while the atomic absorption agrees with the expected complexes formula. Therefore, the octahedral structure for the two complexes is suggested. The anti-corrosion activity of the synthesized compounds were investigated under two temperatures (298 and 308 K) with 0.03 gm of each compound was tested. According to the results cobalt (II) complex shows a better anti-corrosion activity (93%) in comparison with the ligand and nickel (II) complex. KEY WORDS: Cobalt(II) and nickel(II) azo complexes, Imidazole derivative, Anti-corrosion effect Bull. Chem. Soc. Ethiop. 2024, 38(4), 963-971. DOI: https://dx.doi.org/10.4314/bcse.v38i4.12

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Metal complexes of Proline-Azo Dyes, Synthesis, Characterization, Dying Performance and Antibacterial Activity Studies

Cited by 10 publications

References 5 publications

Synthesis and Characterization of some new heterocyclic derivatives from aromatic carbonyl ‎compounds and carboxylic acids with Evaluation some of them for biological activity

Synthesis and Characterization of some new heterocyclic derivatives from aromatic carbonyl ‎compounds and carboxylic acids with Evaluation some of them for biological activity

Metal Complexes of Adenine Azo Ligand: Synthesis, Identification and Study some of their Applications

Co(II) and Ni(II) complexes with bis(4-((E)-(4,5-diphenyl-1H-imidazol-2-yl)diazenyl) phenyl)methane: synthesis, characterization and anti-corrosion effect investigation

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