Metal complexes of thiosemicarbazones for imaging and therapy

Synthesis, Spectroscopic and Quantum Chemical Studies of a Novel Cis-dioxomolybdenum(vi) Thiosemicarbazonate Complex

“…Thiosemicarbazones with an extra oxygen-containing donor to make an ONS donor set have been used successfully as tridentate chelating ligands with many metal ions, including the MoO 2 2+ core. [5]. Asymmetric molybdenum(VI) dioxo complexes of the bis(phenolate) ligands afforded high oxygen atom transfer (OAT) mechanism from dimethylsulfoxide to trimethylphosphine at 65°C.…”

Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity

“…TSCs and their metal complexes are extensively investigated as they exhibit a wide range of pharmacologically interesting properties like anticancer, antibacterial, antiparasitic, and antiviral effects [2]. Especially N)-heterocyclic TSCs exert significant antitumor activity in vitro and in vivo [2,3].…”

“…TSCs and their metal complexes are extensively investigated as they exhibit a wide range of pharmacologically interesting properties like anticancer, antibacterial, antiparasitic, and antiviral effects [2]. Especially N)-heterocyclic TSCs exert significant antitumor activity in vitro and in vivo [2,3]. Triapine (3-aminopyridine-2-carbaldehyde thiosemicarbazone, 3-AP, Chart 1) is the most prominent representative among the α(N)-pyridyl TSCs since it has already been tested in many phase I and II clinical trials [4].…”

“…In general, this arrangement of the donor atoms for α(N)-pyridyl TSCs is also suitable for the binding of other transition metal ions, e.g. Cu(II), Zn(II), Ru(III), Pt(II), and Pd(II), which can result in complexes with even higher cytotoxicity than that of the metal-free ligands [2]. In our previous works we pointed out that dimethylation of the terminal nitrogen strongly enhances the cytotoxicity of α(N)-pyridyl TSCs, especially in the absence of any NH 2 group in the molecule [7].…”

“…In addition, to the effects of the free ligands, also a wide range of metal complexes of tridentate TSCs with remarkable biological effect has been reported in the literature including copper [13][14][15], platinum [16], or vanadium compounds [2,17,18]. With regards to vanadium, complexes of α(N)-pyridyl TSCs formed with oxovanadium(IV) and dioxovanadium(V) were pH-potentiometric, UV−vis, and 1 H NMR titrations [8].…”