Metal complexes with tropolones

Labeling of Hinokitiol with 90Y for Potential Radionuclide Therapy of Hepatocellular Carcinoma

“…Tropolone derivatives are known to form lipophilic complexes with a wide range of metals [56]. Metal complexes based on tropolones demonstrate higher stability than with β-diketones [57,58].…”

“…Yttrium is a trivalent metal, but favors a high coordination number (7 or 8). Depending on reaction conditions, chelating yttrium with tropolonate ligand (L) may lead to the formation of either YL 3 or YL 4 + [56,68,69]. To complete the coordination sphere in the case of YL 3 , the metal can bind a solvent molecule or the complexes tend to form small oligomers (YL 3 ) n (n = 2-3), with increased lipophilicity and poor solubility in the aqueous phase [48,68].…”

“…An amount of 1 mL of freshly prepared 90 Y-hinokitiol (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64) in Lipiodol phase was taken with a syringe and put into a 12-mL flat bottom glass vial, containing 10 mL of physiological serum (previously weighed), and the vial was closed. Activity in the vial was measured with the dose calibrator.…”

Retraction Notice

“…The governance measures used in both studies are related to the general quality of institutions of a country and not specific to activities related to environmental governance. 22 To rectify this gap, our study uses specific measures for environmental governance.…”

Lanthanide DO3A‐Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium

“…[8] Its p K a is around 7 and the tropolonate anion can act as a bidentate ligand for alkaline earth, transition metal and lanthanide ions. [8,9] The electronic structure of the coordinated tropolone moiety enables it to be an efficient sensitizer for several NIR-emitting Ln 3+ ions in solution [10] However, the thermodynamic stability and kinetic inertness of lanthanide tropolonato complexes is not sufficient for in vivo applications. [9] …”