Metal complexes with α-picolinic acid frameworks and their antitumor activity

Efficient removal of uranium from the kidneys by a picolinate-based pentadentate chelator

“…For instance, its complexes with Pt, Pd, Ru, Os, and Ir are shown to have significant anti-tumour activity. 23 Additionally, the macrocyclic ligand featuring multiple picolinate arms exhibits a binding preference towards 225 Ac, 223 Ra, etc., 24,25 thereby enabling effective radiolabelling and advancing the development of highly in-demand alpha-radiopharmaceuticals. Furthermore, a picolinate-based pentadentate ligand, Bis(pyridyl-6-methyl-2carboxylate)-ethylamine (H 2 dpaea), is identified with the capability of stabilizing U(V) (UO 2 + ) in water and binding U(VI)…”

“…For instance, its complexes with Pt, Pd, Ru, Os, and Ir are shown to have significant anti-tumour activity. 23 Additionally, the macrocyclic ligand featuring multiple picolinate arms exhibits a binding preference towards 225 Ac, 223 Ra, etc. , 24,25 thereby enabling effective radiolabelling and advancing the development of highly in-demand alpha-radiopharmaceuticals.…”

Modulating anti-inflammatory and anticancer properties by designing a family of metal-complexes based on 5-nitropicolinic acid

“…Significant antitumoral effects have been reported by several metal complexes (Cu II , Ru II , Re I , Os II , Ir III , Pt IV , and lanthanides) based on picolinic acid derivatives. [35][36][37][38][39][40][41][42][43][44][45] Furthermore, we have previously shown that the nitro group could improve the anticancer properties of an organic ligand. 46 For all of these reasons, the cytotoxic activity of complexes 1-6 and free 5-npic ligand against three cancer cell lines (B16-F10-murine melanoma cells, HT29-colon-cancer cells, and HepG2-hepatoma cells) was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.…”

A Short Review on Structural Concepts of Metal Complexes of Proton Transfer Salts of Pyridine-2-Carboxylic Acid

“…Pyridine carboxylates containing two functional groups are among the most versatile ligands that can coordinate with metal (1). Studies with such molecules have mainly focused on the development of metal-based compounds containing pyridine-2-carboxylic acid (2-picolinic acid) for dietary supplementation and numerous articles and reviews have been conducted (2). Later, such ligands were used for coordination to different transition metals.…”