Metal/covalent-organic framework-based biosensors for nucleic acid detection

The role of terminal coordinated amides in a series of Ca-tatb frameworks: pore size regulation and fluorescence sensing tunability

“…Over the past few decades, FL MOFs have shown significant potential as effective chemical sensors. 29–32 Herein, FL sensing performances of these MOFs are evaluated in response to nitro-molecules, in order to investigate the relationship between their pore structures and their properties. As shown in Fig.…”

“…In the past two decades, there have been significant advancements in the field of metal organic frameworks (MOFs) due to their abundant structural features and various promising applications. 1–5 As a unique characteristic, the pore structures of MOFs could be tailored based on their designable characteristics. The tunability of the pore environment and size is of great importance to MOF materials and can provide specific active sites for catalysis, alter pore size distributions for adsorption and separation, monitor channel dimensionalities for energy applications, and so forth.…”

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

“…[39,100] Moreover, when fluorescently labeled nucleic acid molecules are adsorbed onto the COF surface, the broad-spectrum light-absorption capacity of COFs leads to fluorescence quenching, enabling quantitative nucleic-acid analysis. [101] The adsorption of therapeutic nucleic acid molecules is also beneficial for gene therapy. [102] Recently, Dong et al [53y] synthesized an iminium-linked cationic ABMBP-COF for efficient in vitro and in vivo small interfering RNA (siRNA) delivery using a three-component reaction and subsequent ion exchange with 3-bromopyruvate (BP À ) (Figure 8B).…”

MOF-mediated dual energy transfer nanoprobe integrated with exonuclease III amplification strategy for highly sensitive detection of DNA

“…11–15 Considering their large surface area, tunable pore sizes, significant adsorption affinity, and excellent fluorescence quenching ability, various MOF-based biosensors have been successfully designed and applied in sensing applications. 16–18 For example, Zhang et al developed an effective DNA detection fluorescence sensing platform employing the fluorescence quenching ability and differential binding of ssDNA and dsDNA by UiO-66-NH 2 . 19 Qiu et al demonstrated that aptamer sensors based on UiO-66 not only inherit the superior target recognition ability but also considerably enhance the analytical signal intensity of the sensor.…”