Metal Derivatives of Thiosemicarbazones: Crystal and Mole­cular Structures of Mono‐ and Dinuclear Copper(II) Complexes with N¹‐Subsitituted Salicylaldehyde Thiosemicarbazones

Abstract

Reactions of copper(II) acetate with N 1 -subsitituted salicylaldehyde thiosemicarbazones [R 1 R 2 C 2

The Effect of C‐2 Substituents of Salicylaldehyde‐Based Thiosemicarbazones on the Synthesis, Spectroscopy, Structures, and Fluorescence of Nickel(II) Complexes

“…Type II is observed only in a mixed‐metallic Ru–Ni octanuclear complex,42 and Type III is shown by the pyridyl‐ and 2‐hydroxy‐based bis(thiocarbohydrazones) 43. Type IV has been observed in one dinuclear Cu II complex of salicylaldehyde‐ N ‐ethylthiosemicarbazone44 and in several Ni II complexes reported in this paper.…”

“…The mono(thiosemicarbazones) used in this investigation have shown O,N 3 ,S chelation with N‐2 bridging (Type IV mode) in dinuclear complexes 1 – 7 and are new examples of this type. Previously, we reported the Type IV mode in one dinuclear Cu II complex [Cu 2 L 2 (bipy)] (R 1 = 2‐HO‐C 6 H 4 , R 2 = H, R 3 = Et) with a 5,4‐coordination pair 44. Mono(thiosemicarbazones) with Ni II /Cu II ions in the presence of 2,2′‐bipyridine, 4,4′‐biyridine, or terpyridyl auxiliary ligands have yielded a dinuclear complex [Ni 2 L 2 (bipy)]7b with a 6,4‐coordination pair (R 1 = 2‐HO‐C 6 H 4 , R 2 = CH 3 , R 3 = H), 4,4′‐biyridyl‐bridged dinuclear complexes [M 2 L 2 (μ‐4,4′‐bipy)] (M = Ni, Cu, L is an O , N , S ‐chelating dianion; R 1 = 2‐HO‐C 6 H 4 , R 2 = H, R 3 = H, Ph, 4‐MeOC 6 H 4 ),7a,7c,7d,8 or an octahedral [NiL(terpy)] complex (R 1 = 2‐HO‐C 6 H 4 , R 2 = H, R 3 = H, terpy = terpyridine) 7b.…”

“…The [Ni 2 L 2 (bipy)] complex does not have N‐2 bridges; instead one O and one S atom act as a heterobridge between two Ni metal centers with a central Ni(μ‐O,S‐L)Ni core 7b. 2,2′‐Bipyridine and dmbipy have yielded distorted trigonal‐bipyramidal Cu II complexes [CuL(L′)] (L′ = dmbipy, L is an O , N , S ‐chelating dianion; R 1 = 2‐HO‐C 6 H 4 , R 2 = H, R 3 = Ph, cycohexyl; L′ = bipy, R 1 = 2‐HO‐C 6 H 4 , R 2 = H, R 3 = Ph, Me) 9,10,44. Likewise, Zn II has formed a five‐coordinate complex [ZnL(bipy)] (R 1 = 2‐HO‐C 6 H 4 , R 2 = H, R 3 = cycohexyl) 11.…”

Spectroscopic, electrochemical and X-ray diffraction studies on nickel(II)-complexes of acetophenone thiosemicarbazones substituted six-carbon groups

“…Metal-phosphine complexes have a second ligand that contains both soft and hard donor atoms. These ligands are preferred a special significance due to their biological potentials [4][5][6][7]. Among them, thiosemicarbazones have been of particular interest since the discovery of their antiviral [8,9] antibacterial [10] and cytotoxic activities [11,12].…”

Synthesis and structures of 5-nitro-salicylaldehyde thiosemicarb-azonates of copper(ii): molecular spectroscopy, ESI-mass studies, antimicrobial activity and cytotoxicity

“…9,[16][17][18] The major reason for continued research in the use of thiosemicarbazones lies in their applications, specically biological ones, either as free ligands 19 or as their metal complexes. 4,9 Owing to our experience in the synthetic coordination chemistry of thiosemicarbazones with various metals (Ni, Pd, Ru Cu, Ag, Au, Hg, Co), 9,[20][21][22][23][24][25][26][27][28][29] and our recent attempt in investigating the anti-microbial properties of copper(II) complexes, 30 we believed it worthwhile to pursue this area further, the results of which are reported in this paper. However a critical account of the biological applications of metal thiosemicarbazones is briey reviewed here so as to provide the reader with glimpses of the work being pursued in different laboratories.…”