Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2<i>H</i>-chromen-2-one Derivatives and Their Biological Evaluation

Merugu, Shivanand; Ponnamaneni, Vijaya Kumar; Varala, Ravi; Adil, Syed Farooq; Khan, Mujeeb; Vemula, Ravikumar

doi:10.1155/2020/4869279

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…It showed a shift towards at high frequencies except for gold complex in CSC band, it has been shifted towards the lower frequency. This shift indicates the coordination occurrence through the imine group, nitrogen ring of the thiadiazole, and S as tridentate ligand (17). The spectra of all the complexes show the additional medium intensity bands in the range 519-470, 470-412, and 369-320 cm -1 assigned to the υ(M-N), υ(M-S), and υ(M-Cl), respectively (18,21).…”

Section: Fourier Transforms Spectroscopy (Ft-ir) Of Ligand and Their ...mentioning

confidence: 90%

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2023

J. Med. Chem. Sci.

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The Schiff-Mannich base was derived from 1,3,4 thiadazole prepared by combining of 2-amino-5-mercapto-1,3,4 thiadazole and 4-N,N-dimethyl benzaldehyde with indol. The result compound was 5-((1 H-ind ol -1-yl) methylthio)-N-(4-(dimethylamino)benzylidene)-,1,3,4-thiadiazol-2-amine(L), coordinated with six metal ion Co(II), Ni(II), Cu(II), Pd(II), Pt(IV), and Au(III). The ligand (L) has been characterized by using the following techniques, C.H.N.S, FT-IR, UV-ViS, 1 H-NMR, and 13 C-NMR. In addition, the measurement of (atomic absorption spectra, magentic susceptibility, and molar conductivity) was used when diagnosing the complexes. The experimental results showed that the ligands coordinated as tri-dentate with metal ions. The antibacterial and antifungal activity of all complexes were studied against Staphylococcus aureus and Bacillus subtilis as a model of gram-positive, as well as E-coli and Klebsiella pneumoniae as a gram-negative at a concentration of 0.02 M. Likewise, the effectiveness of the prepared compounds was determined in inhibiting selected types of bacteria and fungi. The results showed that the prepared metal complexes and ligand are more effective than the standard drug in bacteria and fungi. The metal to ligands ratio was determined by the molar ratio method and showed the metal interaction with the ligand proportion (1:1). Also, the compounds prepared were studied in gas phase by using the hyper-chem8.0.7 program. Through this program, the heat of formation, binding energy, HOMO and LUMO, and the electrostatic potential in addition to the infrared vibration of the ligand were calculated.

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Section: Fourier Transforms Spectroscopy (Ft-ir) Of Ligand and Their ...mentioning

confidence: 90%

“…The prepared concentrations were added to the holes (0.2 mL) by micropipette per hole with the control hole kept on the DMSO, and then the dishes were incubated in the incubator for 72 hours at 28 °C. The diameter of the zone inhibition was known by the means of a ruler around each well (17).…”

Section: Antifungal Activitymentioning

confidence: 99%

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2023

J. Med. Chem. Sci.

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1,3,4-Thiadiazole Scaffold: Anti-Microbial Agents

2022

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1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents

Anthwal

Nain

2022

Front. Chem.

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A wide range of biological activities is exhibited by 1,3,4-thiadiazole moiety such as antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antiviral, antihypertensive, and antimicrobial. To date, drugs such as butazolamide, and acetazolamide. Several modifications have been done in the 1,3,4-thiadiazole moiety which showed good potency as anticonvulsant agents which are highly effective and have less toxicity. After in-depth literature survey in this review, we have compiled various derivatives of 1,3,4-thiadiazole scaffold as anticonvulsant agents.

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Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation

Cited by 3 publications

References 21 publications

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1,3,4-Thiadiazole Scaffold: Anti-Microbial Agents

1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents

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