Metal‐free cross‐dehydrogenative coupling approach for C‐H bond functionalization of 2‐phenyl pyridine derivatives in water

Babu, Gogu V. Surendra; Parvathaneni, Sai Prathima; Perumgani, Pullaiah C.; Sridhar, Balasubramanian; Rao, T. V. S. Ramamohan; Rao, M. Mohan

doi:10.1002/hc.21423

Cited by 5 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rao and co‐workers [38] developed a simple K 2 S 2 O 8 ‐mediated C−H bond functionalization of 2‐phenyl pyridines with ethers involving C sp 3 −C sp 2 cross‐dehydrogenative coupling [Eq. (23)].…”

Section: Cdc Reactions For C−c Bond Formation In Aqueous Mediamentioning

confidence: 99%

Recent Advances in Cross‐Dehydrogenative Couplings (CDC) of C−H Bond in Aqueous Media

Peng

Dong

2021

Adv Synth Catal

View full text Add to dashboard Cite

To develop highly efficient synthetic reactions is quite important in organic chemistry. Cross dehydrogenative couplings (CDC) utilize C−H bonds of substrates to construct new C−X (X=C, S, O, N, P) bonds. For CDC, the pre‐functionalization of reaction substrates can be avoided and the C−X (X=C, S, O, N, P) bonds can be newly formed by simple and efficient synthesis routes. Meanwhile, water is increasingly used as a substitute for organic solvents in cross‐dehydrogenative coupling because of its rich content, non‐toxicity, and non‐ flammability. In recent years, organic chemists are devoted their efforts to explore the cross dehydrogenative couplings (CDC) in aqueous phase which feature high atom utilization rate and environmental friendliness. Herein, we summarized the recent advances in the construction of C−C, C−S, C−O, C−N, and C−P bonds through CDC reactions of C−H bonds in water.

show abstract

Section: Cdc Reactions For C−c Bond Formation In Aqueous Mediamentioning

confidence: 99%

Recent Advances in Cross‐Dehydrogenative Couplings (CDC) of C−H Bond in Aqueous Media

Peng

Dong

2021

Adv Synth Catal

View full text Add to dashboard Cite

show abstract

Recent Advances in Organic Reactions Using Water as Solvent

Wang,

Sun,

Wang

et al. 2024

Green Solvents in Organic Synthesis

View full text Add to dashboard Cite

Ethers as Building Blocks for the Synthesis and Modification of N‐Heterocycles

Grishin,

Mulina,

et al. 2024

Asian J Org Chem

View full text Add to dashboard Cite

The use of C‐H compounds as reactive partners in a variety of transformations represents the state of the art in synthetic methodology. In this review, we have summarized the main achievements in using ethers as building blocks for the construction and modification of one of the basic platforms of organic chemistry, nitrogen‐containing heterocycles. Ethers, previously considered mainly as solvents, are excellent CH‐partners, capable of generating radical or cationic reactive species under the action of HAT agents and oxidants. The challenge in this field is the still limited number of heterocyclic systems and other starting reagents, with which the processes can be carried out selectively due to closer bond dissociation energies and oxidation potentials of heterocycles, reactive intermediates and ethers. However, the fine‐tuning of the reaction system using electro‐ and photochemical approaches and a deep understanding of the reaction pathways make the use of ethers as C‐H reagents a promising synthetic strategy.

show abstract

Metal‐free cross‐dehydrogenative coupling approach for C‐H bond functionalization of 2‐phenyl pyridine derivatives in water

Cited by 5 publications

References 53 publications

Recent Advances in Cross‐Dehydrogenative Couplings (CDC) of C−H Bond in Aqueous Media

Recent Advances in Cross‐Dehydrogenative Couplings (CDC) of C−H Bond in Aqueous Media

Recent Advances in Organic Reactions Using Water as Solvent

Ethers as Building Blocks for the Synthesis and Modification of N‐Heterocycles

Contact Info

Product

Resources

About