2021
DOI: 10.1039/d0ra09392k
|View full text |Cite
|
Sign up to set email alerts
|

Metal-free multicomponent approach for the synthesis of propargylamine: a review

Abstract: Metal-free propargylamines synthesis via multicomponent reactions.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
24
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 45 publications
(24 citation statements)
references
References 105 publications
0
24
0
Order By: Relevance
“…Propargylamine skeletons are not only found in naturally occurring products and drug molecules but also used as important synthons for elegant chemical transformations . As a result of the application potential of propargylamines in organic synthesis, various synthetic methods have been exploited to achieve the synthesis of propargylamine derivatives. However, the research on the synthesis of amino skipped diynes is relatively limited. For example, Lee and Huang developed methods for synthesizing 3-amino-1,4-diynes that rely on stoichiometric quantities of alkynylmetal reagents (Scheme , eq 1a). Zhang and Hajra described the copper-catalyzed coupling of N , N -disubstituted formamides with terminal alkynes, providing 3-amino-1,4-diynes (Scheme , eq 1b).…”
mentioning
confidence: 99%
“…Propargylamine skeletons are not only found in naturally occurring products and drug molecules but also used as important synthons for elegant chemical transformations . As a result of the application potential of propargylamines in organic synthesis, various synthetic methods have been exploited to achieve the synthesis of propargylamine derivatives. However, the research on the synthesis of amino skipped diynes is relatively limited. For example, Lee and Huang developed methods for synthesizing 3-amino-1,4-diynes that rely on stoichiometric quantities of alkynylmetal reagents (Scheme , eq 1a). Zhang and Hajra described the copper-catalyzed coupling of N , N -disubstituted formamides with terminal alkynes, providing 3-amino-1,4-diynes (Scheme , eq 1b).…”
mentioning
confidence: 99%
“…Propargylamines are recurring building blocks and also versatile synthetic intermediatesfor the synthesis of divergent therapeutic drugs and polyfunctional heterocycles. [96] In this regard,aldehyde-alkyne-amine coupling (A 3 coupling)would be an attractive and eco-friendly process sincethree components in one pot generate the propargylamine along with water as the only by-product. Zeng and co-workers have reporteda Fe 3 O 4 nanoparticle-supported copper(I) pyboxcatalyst system which exhibits good reactivity in asymmetric A 3 coupling (Scheme 19).…”
Section: Synthesis Of Propargylaminesmentioning
confidence: 99%
“…Recently, their application in the chemical fixation of carbon dioxide has been also described [4][5][6]. Consequently, a number of methodologies detailing the preparation of these building blocks have been disclosed, mostly involving the direct addition of alkynyl nucleophiles to imines [7][8][9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%