Metal-free photosensitized intermolecular carboimination of alkenes: a green and direct access to both β-amino acids and β-amino ketones

Abstract

β-amino carbonyl substructure is a privileged motif in natural products and active pharmaceutical compounds. Here, we report a photoinduced metal-free and highly regioselective intermolecular carboimination method via simultaneous introduction of...

Recent advances in three-component radical acylative difunctionalization of unsaturated carbon–carbon bonds

“…Soon after, Lin and co-workers developed photoinduced thioxanthone-catalyzed carboimination of alkenes, providing operatively simple and cost-effective access to β-amino acid and β-amino ketone motifs (Scheme 9B). 38 Organic azides have attracted significant attention owing to their unique applications in organic synthesis, material science, and click chemistry. In 2018, Wang and co-workers described a (salen)Mn(III)-catalyzed radical acyl-azidation of olefins (Scheme 10A).…”

“…Soon after, Lin and co-workers developed photoinduced thioxanthone-catalyzed carboimination of alkenes, providing operatively simple and cost-effective access to β-amino acid and β-amino ketone motifs (Scheme 9B). 38…”