2022
DOI: 10.26434/chemrxiv-2022-v1zwx
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Metal-Free S-Arylation of Phosphorothioate Diesters and Re-lated Compounds with Diaryliodonium Salts

Abstract: We developed a direct metal-free S-arylation of phosphorothioate diesters using diaryliodonium salts. The meth-od allows for the preparation under simple conditions of a broad range of S-aryl phosphorothioates, including complex molecules (e.g., dinucleotide- or TADDOL-derivatives), as well as other related organophosphorus compounds arylated at chalcogen. The reaction proceeds with a full retention of the stereogenic center at phos-phorus atom, opening convenient access to P-chiral products. The mechanism of … Show more

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