Abstract:A new and scalable mechanochemical approach has been developed for the synthesis of perimidine derivatives using an efficient and recyclable catalyst, carbon sulfonic acid under metal-free conditions. A wide variety of aldehydes displayed cyclo-condensation reaction with 1,8-diaminonaphthalene in EtOH under ambient reaction conditions via grind-stone technique to produce substituted perimidines in excellent yields (95-99 %) in a very short reaction time. This method has interesting features like single-step sy… Show more
“…This is a signicant step forward in the quest to develop greener and more sustainable methods for synthesizing organic compounds. [52][53][54] [The calculated data is given in the ESI le].…”
Functionalized 1,1-dihomoarylmethane scaffolds (bis-cyclohexanediones, bis-pyrazoles, and bis-coumarins) have been synthesized using g-C3N4·SO3H ionic liquid catalyst via Koevenagel–Michale reaction with high yields and short time.
“…This is a signicant step forward in the quest to develop greener and more sustainable methods for synthesizing organic compounds. [52][53][54] [The calculated data is given in the ESI le].…”
Functionalized 1,1-dihomoarylmethane scaffolds (bis-cyclohexanediones, bis-pyrazoles, and bis-coumarins) have been synthesized using g-C3N4·SO3H ionic liquid catalyst via Koevenagel–Michale reaction with high yields and short time.
“…Therefore, further efforts are needed to present more proficient and eco-benign methods for the synthesis of hexahydroquinoline-3-carbonitriles. In our continuous efforts to utilize eco-friendly catalysts for the green synthesis of nitrogen-based heterocyclic compounds, − we envisioned that the ionic liquid [H 2 -DABCO][HSO 4 ] 2 efficiently catalyzed the Hantzsch-type synthesis of hexahydroquinolines by employing 1,3-dicarbonyl, malononitrile, and ammonium acetate with substituted aldehydes as a coupling partner. To the best of our knowledge and literature studies, this economical, sustainable, and eco-friendly [H 2 -DABCO][HSO 4 ] 2 -catalyzed 1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile synthesis is not reported to date.…”
Green, eco-benign, and sustainable synthesis is paramount in present chemistry. Here, a facile, efficient, and [H 2 -DABCO][HSO 4 ] 2 ionic-liquid-catalyzed one-pot multicomponent synthesis of hexahydroquinolines was reported under ambient reaction conditions. The reaction of 1,3-dicarbonyls, malononitrile, and ammonium acetate with various aldehydes in the presence of an ionic liquid catalyst and EtOH solvent at room temperature afforded excellent yields (76−100%) of hexahydroquinolines under a short reaction time (5−15 min). Mild reaction conditions, broad substrate scope (28 derivatives), and column-chromatography-free synthesis with excellent catalytic efficiency and good recyclability rendered this protocol superior and practical. The greenness of the present method was assessed through eco-score and E-factor. The significant results in gram-scale synthetic conditions validate its applicability in industries as well as academia in the near future.
“…Encouraged by the promising catalytic activity of our previously synthesized and characterized glycerol based carbon sulfonic catalyst [ 33 , 34 , 35 ], a facile protocol for the synthesis of isonicotinohydrazide analogs using glycerol based sulfonic acid as a catalyst has been demonstrated ( Scheme 1 ). Scheme 1 Synthesis of isonicotinohydrazide analogs using isoniazid and aldehydes.…”
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