Metal-Free Synthesis of Thiocyanated Aminonitroalkenes and 2-Aminothiazoles/selenazoles from β-Aminonitroalkenes and N‑Thio/Selenocyanatosaccharin

Abstract

A convenient and efficient protocol has been developed for the synthesis of thiocyanated aminonitroalkenes and 2,4,5-trisubstituted thiazoles/selenazoles from β-aminonitroalkenes and N‑thio/selenocyanatosaccharin. This method features simple operation, mild reaction conditions, short reaction time, good functional group compatibility and metal-free characteristics. The broad applications of polysubstituted thiazoles/selenazoles in organic and medicinal chemistry make this protocol much more practical.