Metal Induced Genotoxicity and Oxidative Stress in Plants, Assessment Methods, and Role of Various Factors in Genotoxicity Regulation

Tabassum,; Jeena, A.S.; Pandey, Deepak

doi:10.1007/978-981-16-2074-4_5

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…At 1.5 mM Pb stress, both strains reduced lipid peroxidation by 41. 42 Further, the efficacy of Pb-resistant strains M. morganii strains (ABT3 and ABT9) on photosynthetic efficiency of Arabidopsis plants was observed in terms of quantum yield (Fv/Fm) and chlorophyll content. Results showed that Pb stress significantly reduced chlorophyll content and Fv/Fm, while inoculation with Pb-resistant M. morganii strains (ABT3 and ABT9) promoted these parameters significantly (Figure 4).…”

Section: Resultsmentioning

confidence: 99%

“…Lead also induces structural damage, decreases physiological and biochemical activity, and impairs enzyme activities involved in the Calvin cycle and nitrogen and sugar metabolism [40]. Higher Pb concentrations may result in ROS production, triggering oxidative stress, cell membrane damage, and DNA strand breakage, thus resulting in decreased plant development [41,42].…”

Section: Discussionmentioning

confidence: 99%

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Lead-Resistant Morganella morganii Rhizobacteria Reduced Lead Toxicity in Arabidopsis thaliana by Improving Growth, Physiology, and Antioxidant Activities

et al. 2022

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Biological remediation serves as a powerful technique for addressing heavy metals toxicity in metals-contaminated soils. The present study aimed to evaluate the efficacy of lead (Pb)-resistant rhizobacterial strains on growth, photosynthetic traits, and antioxidant activities of the Arabidopsis plant under lead toxicity in pot conditions. Two pre-isolated and pre-characterized Pb-resistant Morganella morganii (ABT3) and Morganella morganii (ABT9) strains were used for inoculating Arabidopsis plants grown under varying Pb concentrations (1.5 mM and 2.5 mM) using PbNO3 as the lead source. The treatments were set up in a completely randomized design with four replications. Data on growth parameters, physiological characteristics, lipid peroxidation, and antioxidant activities were recorded at harvesting. It was observed that Pb contamination caused a significant reduction in Arabidopsis growth, chlorophyll content and quantum yield at both lead concentrations. The Pb concentration of 2.5 mM, showed a substantial decrease in all parameters, including shoot fresh weight (58.72%), shoot dry weight (59.31%), root fresh weight (67.31%), root dry weight (67.28%), chlorophyll content (48.69%), quantum yield (62.36%), catalase activity (65.30%), superoxide dismutase (60.88%), and peroxidase activity (60.54%) while increasing lipid peroxidation (113.8%). However, the inoculation with Pb-resistant M. morganii strains (ABT3 and ABT9) improved plant growth, photosynthesis and antioxidant activities, while reduced the malondialdehyde content of Arabidopsis compared to control plants without inoculation. The M. morganii strain ABT9 showed a maximum increase in the shoot fresh weight (67.18%), shoot dry weight (67.96%), root fresh weight (94.04%), root dry weight (93.92%), shoot length (148.88%), root length (123.33%), chlorophyll content (52.53%), quantum yield (58.57%), catalase activity (39.46%), superoxide dismutase (21.84%), and peroxidase activity (22.34%) while decreasing lipid peroxidation (35.28%). PCA analysis further showed that all nine treatments scattered differently across the PC1 and PC2, having 81.4% and 17.0% data variance, respectively, indicating the efficiency of Pb-resistant strains. The heatmap further validated that the introduction of Pb-resistant strains positively correlated with the growth parameters, quantum yield, chlorophyll content and antioxidant activities of Arabidopsis seedlings. Both Pb-resistant strains improved Arabidopsis plant growth and photosynthetic efficiency under lead stress conditions. Thus, both Morganella morganii ABT3 and Morganella morganii ABT9 strains can be considered as bio-fertilizer for reducing lead toxicity thereby improving plant growth and physiology in metal-contaminated agricultural soils.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lead-Resistant Morganella morganii Rhizobacteria Reduced Lead Toxicity in Arabidopsis thaliana by Improving Growth, Physiology, and Antioxidant Activities

et al. 2022

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“…Genotoxicity includes all adverse effects on the genome, including damage to genetic materials such as DNA and some cellular components such as spindle apparatus, DNA polymerases, and DNA repair systems that are involved in the cell cycle and cell division (Tabassum and Pandey, 2021). Trace metals such as Pb, As, Ni, Hg, Cr, and Cd are well known genotoxins and can cause DNA damage in plant cells.…”

Section: Genotoxicitymentioning

confidence: 99%

“…Arsenite [As(III)] reacts with sulfhydryl groups of enzymes required for the synthesis of genetic materials (Yager and Wiencke, 1997). Although the exact mechanisms of oxidative stress-mediated DNA damage have not been clarified, oxidative damage to DNA through a Fenton-like reaction appears to be a plausible mechanism (Tabassum and Pandey, 2021).…”

Section: Genotoxicitymentioning

confidence: 99%

Molecular mechanisms underlying the toxicity and detoxification of trace metals and metalloids in plants

Tang

Wang

Chen

et al. 2023

JIPB

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Plants take up a wide range of trace metals/metalloids (hereinafter referred to as trace metals) from the soil, some of which are essential but become toxic at high concentrations (e.g., Cu, Zn, Ni, Co), while others are non-essential and toxic even at relatively low concentrations (e.g., As, Cd, Cr, Pb, and Hg). Soil contamination of trace metals is an increasing problem worldwide due to intensifying human activities. Trace metal contamination can cause toxicity and growth inhibition in plants, as well as accumulation in the edible parts to levels that threatens food safety and human health. Understanding the mechanisms of trace metal toxicity and how plants respond to trace metal stress is important for improving plant growth and food safety in contaminated soils. The accumulation of excess trace metals in plants can cause oxidative stress, genotoxicity, programmed cell death, and disturbance in multiple physiological processes. Plants have evolved various strategies to detoxify trace metals through cell-wall binding, complexation, vacuolar sequestration, efflux, and translocation. Multiple signal transduction pathways and regulatory responses are involved in plants challenged with trace metal stresses. In this review, we discuss the recent progress in understanding the molecular mechanisms involved in trace metal toxicity, detoxification, and regulation, as well as strategies to enhance plant resistance to trace metal stresses and reduce toxic metal accumulation in food crops.

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“…Protein oxidation can hinder enzyme activities and disrupt critical cellular processes. ROS-induced DNA damage can lead to mutations and genomic instability, affecting cell division and plant growth [160,161]. SODs contribute to the protection of essential cellular components, such as proteins, lipids, and DNA, from oxidative damage caused by heavy metal-induced ROS.…”

Section: Reactive Oxygen Species Productionmentioning

confidence: 99%

Analysis of Heavy Metal Impacts on Cereal Crop Growth and Development in Contaminated Soils

Vasilachi,

Stoleru,

Gavrilescu

2023

Agriculture

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The impact of heavy metal presence in soil on cereal crops is a growing concern, posing significant challenges to global food security and environmental sustainability. Cereal crops, vital sources of nutrition, face the risk of contamination with toxic heavy metals released into the environment through human activities. This paper explores key aspects requiring thorough investigation to foster innovation and understand intricate interactions between heavy metals and cereals. Visible symptoms and physiological changes resulting from heavy metal contamination, such as chlorosis and stunted growth, demand further research to devise targeted mitigation strategies and sustainable agricultural practices. Root barrier formation, mycorrhizal symbiosis, and metal-binding proteins emerge as critical defence mechanisms for combating heavy metal stress, offering opportunities for developing metal-tolerant cereal varieties. Research on metal bioavailability and food safety implications in cereal grains is vital to safeguard human health. This paper reveals that multidisciplinary collaboration and cutting-edge technologies are essential for promoting innovation beyond the state of the art in elucidating and mitigating the impacts of heavy metals on cereal crops. Genetic and breeding approaches show promise in developing metal-tolerant cereal varieties, while agronomic practices and soil amendments can reduce metal bioavailability and toxicity. Unravelling the complex mechanisms underlying heavy metal uptake and tolerance is essential for sustainable cereal agriculture and worldwide food sustainability. Embracing the challenges of heavy metal pollution through proactive research and collaboration can secure a resilient future for cereal crops amid evolving environmental conditions.

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Metal Induced Genotoxicity and Oxidative Stress in Plants, Assessment Methods, and Role of Various Factors in Genotoxicity Regulation

Cited by 8 publications

References 29 publications

Lead-Resistant Morganella morganii Rhizobacteria Reduced Lead Toxicity in Arabidopsis thaliana by Improving Growth, Physiology, and Antioxidant Activities

Lead-Resistant Morganella morganii Rhizobacteria Reduced Lead Toxicity in Arabidopsis thaliana by Improving Growth, Physiology, and Antioxidant Activities

Molecular mechanisms underlying the toxicity and detoxification of trace metals and metalloids in plants

Analysis of Heavy Metal Impacts on Cereal Crop Growth and Development in Contaminated Soils

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