Metal‐induced oxidative damage in cultured hepatocytes and hepatic lysosomal fraction: beneficial effect of a curcumin/absinthium compound

Abstract

These data support the potential clinical application of curcumin-containing compounds.

Specific Inhibition of NEIL-initiated Repair of Oxidized Base Damage in Human Genome by Copper and Iron

“…It was proposed that the ability of curcumin to bind toxic metals and to form tight and inactive complexes could be a plausible pathway by which curcumin offers protection to the brain (76). In fact, the ability of curcumin to bind to several metals (51,74,77) and thereby potentially reduce their toxicity is well documented. The interaction of curcumin with copper and iron reaches half-maximum at ϳ3-12 and 2.5-5 M levels, respectively (77).…”

Autophagy and ethanol-induced liver injury

“…Some of the current evidence for this is circumstantial, but nevertheless compelling as there is evidence of lysosomal damage, as judged by enhanced lysosomal fragility, which could result from either altered lipid metabolism, oxidative stress or both [15] . By analogy, other instances of lysosome fragility by iron-induced oxidative stress are documented [38,39] . However, ethanol administration has little to no effect on the activities of lysosomal hydrolases [31] and, because a significant number of cathepsins rely on a reduced sulfhydryl group for their catalytic activity in their active centers, the alteration of lysosomal glutathione or cysteine content by ethanol seems unlikely.…”

The root extract of Paeonia lactiflora Pall inhibits the oxidative damage via its anti-oxidant activity

“…When present in a high enough concentration, these compounds can damage cellular proteins and DNA, or form DNA adducts that may promote carcinogenic activity 16) . This DNA damage induced by hydroxyl radical has been shown to play a key role in the carcinogenesis 17) . In addition, a possible mechanism of oxidative DNA damage induced by metals is thought to be the formation of hydroxyl radicals through Fenton-type reduction with hydrogen peroxide, which is naturally present in cells 18) .…”