Metal ion size profoundly affects H₃glyox chelate chemistry

Abstract

The bisoxine hexadentate chelating ligand, H3glyox was investigated for its affinity for Mn2+, Cu2+ and Lu3+ ions; all three metal ions are relevant with applications in nuclear medicine and medicinal inorganic chemistry.

Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives

“…Furthermore, H 2 pyhox proved to be suitable for 225 Ac III [112]. Smaller radiometal ions such as 44 Sc III , 68 Ga III and 111 In III are efficiently complexed with H 3 glyox, a ligand containing glycine and oxine donor groups [113]. This ligand shows interesting fluorescence properties after the addition of metal ions and is thus a promising system for nuclear/optical imaging [114].…”

Novel [68Ga/177Lu]Ga/Lu-AZ-093 as PSMA-Targeting Agent for Diagnosis and Radiotherapy

“…Advantages and disadvantages of macrocyclic DOTA, NOTA, and their related chelating groups, DOTAGA, α-(2-carboxyethyl)-1,4,7,10 tetraazacyclododecane-1,4,7,10-tetraaceticacid, NOTAGA, 1,4,7-triazacyclononane-1-glutaric acid-4,7-acetic acid, , etc., have been reviewed. − In addition, series of acyclic chelators, DTPA, HBED, AAZTA, etc., , have been reported. Many DOTA and DTPA derivatives have been successfully developed in recent years as new chelating agents by which forming stable metal complexes with enhanced properties for radiopharmaceuticals. ,,− Originally, AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid), a heptadentate chelator, was first reported by Aime et al designed to form gadolinium (Gd) complexes as MRI contrast imaging agents. It was reported that AAZTA is also a promising chelator for gallium-68 or scandium-44. , Promising AAZTA-based bifunctional chelators for preparation of analogs of [ 68 Ga]­Ga-DOTA-TOC (NETSOPT), [ 68 Ga/ 44 Sc/ 177 Lu]­Ga/Sc/Lu-AAZTA-TOC. , as well as [ 68 Ga]­Ga-AAZTA-PSMA derivatives were prepared and evaluated.…”