Metal ions and complexes as modulators of protein-interfacial electron transport at graphite electrodes

Armstrong, Fräser A.; Cox, P. A.; Hill, H. Allen O.; Lowe, Valerie J.; Oliver, B. Nigel

doi:10.1016/0022-0728(87)80228-0

Cited by 167 publications

(89 citation statements)

References 86 publications

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“…Surprisingly, the heterogenous rate constant determined for CpFd, which agrees with previously reported ones (29,30), is closer to those of CvFd cluster II than to those of CvFd cluster I (Table III). This is another noteworthy difference between the latter and CpFd clusters, despite their structural similarity (10).…”

Section: [4fe-4ssupporting

confidence: 90%

The Two [4Fe-4S] Clusters in Chromatium vinosumFerredoxin Have Largely Different Reduction Potentials

Kyritsis¹,

Hatzfeld²,

Link³

et al. 1998

Journal of Biological Chemistry

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Section: [4fe-4ssupporting

confidence: 90%

The Two [4Fe-4S] Clusters in Chromatium vinosumFerredoxin Have Largely Different Reduction Potentials

Kyritsis¹,

Hatzfeld²,

Link³

et al. 1998

Journal of Biological Chemistry

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“…rate of 5 mV/s. A pair of well-defined redox peaks were observed on the Hi-Ns-TiO 2 -coated electrode at E pc = 0.033 V, E pa = 0.103 V, with a separation of 70 mV, which can be attributed to the quasi-reversible redox process of the heme group of cyt c. The formal potential was 0.068 V, and the cathodic and anodic peak currents were nearly equal to each other, which is in good agreement with the reported characteristics of a native cyt c [26][27][28]. In contrast, a pair of rather ill-defined peaks with a lower faradaic current (~74%) and a high capacitance current was obtained on the Np-TiO 2 -coated electrode in the same solution.…”

Section: Electrochemical Impedance Characterization Of Urchin-like Hisupporting

confidence: 87%

Direct electrochemistry of cytochrome c at a hierarchically nanostructured TiO2 quantum electrode

et al. 2010

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Monodisperse TiO 2 nanoparticles and urchin-like hierarchical TiO 2 nanospheres assembled with ultrathin quantum nanowires (about 2 nm) have been synthesized by a simple template-free wet chemical method. The morphology, structure, and crystallinity of the TiO 2 nanomaterials were investigated by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and high resolution transmission electron microscopy (HRTEM). Electrochemical measurements with the hierarchically nanostructured TiO 2 nanospheres as an electrode showed much better reversibility for direct electrochemistry of cytochrome c (cyt c) and much higher sensitivity than for an electrode composed of the monodisperse TiO 2 nanoparticles. The excellent performance of the hierarchical TiO 2 nanospheres may result from a quantum size effect, and their favorable nanostructure (with the presence of an abundance of both uniform macropores and mesopores), excellent structural stability and high specific surface area. The relative ionic strength had significant effect on the direct electrochemistry. Very high ionic strengths relative to cyt c concentration (I/c) induced a conformational change of cyt c on the nanostructure-coated electrode, from the native state to a partially unfolded one in 25 mmol/L phosphate buffer solution (pH 6.8).

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“…Carbon electrodes possess a highly functionalized surface and a net negative charge for pH/5.6 [12]. In this case, well-behaved electrochemistry of redox proteins with the appropriate positive charge has been observed in the absence of an added modifier [13].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, a polished edge plane surface possesses many more carbon oxide functionalities than a basal surface. Accordingly, good voltammetric responses with cationic proteins like cytochrome c have been reported at the edge plane electrode while very poor responses are obtained at the basal electrode [14,12]. In the case of negatively charged proteins, promotion of electron transfer has been successfully achieved in the presence of positively charged species [12,15Á/17].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical studies on small electron transfer proteins using membrane electrodes

Santos¹,

Sousa²,

Gonçalves³

et al. 2003

Journal of Electroanalytical Chemistry

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Membrane electrodes (ME) were constructed using gold, glassy carbon and pyrolytic graphite supports and a dialysis membrane, and used to study the electrochemical behavior of small size electron transfer proteins: monohemic cytochrome c 522 from Pseudomonas nautica and cytochrome c 533 as well as rubredoxin from Desulfovibrio vulgaris . Different electrochemical techniques were used including cyclic voltammetry (CV), square wave voltammetry (SW) and differential pulse voltammetry (DP). A direct electrochemical response was obtained in all cases except with rubredoxin where a facilitator was added to the protein solution entrapped between the membrane and the electrode surface. Formal potentials and heterogeneous charge transfer rate constants were determined from the voltammetric data. The influence of the ionic strength and the pH of the medium on the electrochemical response at the ME were analyzed. The benefits from the use of the ME in protein electrochemistry and its role in modulating the redox behavior are analyzed. A critical comparison is presented with data obtained at non-MEs. Finally, the interactions that must be established between the proteins and the electrode surfaces are discussed, thereby modeling molecular interactions that occur in biological systems. #

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Metal ions and complexes as modulators of protein-interfacial electron transport at graphite electrodes

Cited by 167 publications

References 86 publications

The Two [4Fe-4S] Clusters in Chromatium vinosumFerredoxin Have Largely Different Reduction Potentials

The Two [4Fe-4S] Clusters in Chromatium vinosumFerredoxin Have Largely Different Reduction Potentials

Direct electrochemistry of cytochrome c at a hierarchically nanostructured TiO2 quantum electrode

Electrochemical studies on small electron transfer proteins using membrane electrodes

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