2023
DOI: 10.1039/d3bm01146a
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Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

Yankun Luo,
Hanghang Liu,
Yaowen Zhang
et al.

Abstract: In recent years, bone regeneration has emerged as a remarkable field that offers promising guidance for treating bone-related diseases, such as bone defects, bone infections, and osteosarcoma. Among various bone...

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Cited by 16 publications
(3 citation statements)
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“…Owing to their great biocompatibility with many other beneficial effects, metal ions are prevalent in doping HA to produce metal ion-doped HA-based materials. These materials have a broad application prospect in restoring bone defect [88]. However, there are still some challenges, namely incomplete clarification of the mechanism of bone defect restoration, insufficient improvement of the properties in vitro, and rare in vivo tests, that need to be solved.…”
Section: Discussionmentioning
confidence: 99%
“…Owing to their great biocompatibility with many other beneficial effects, metal ions are prevalent in doping HA to produce metal ion-doped HA-based materials. These materials have a broad application prospect in restoring bone defect [88]. However, there are still some challenges, namely incomplete clarification of the mechanism of bone defect restoration, insufficient improvement of the properties in vitro, and rare in vivo tests, that need to be solved.…”
Section: Discussionmentioning
confidence: 99%
“…The commonly used metal ions for bone regeneration are Mg 2+ , calcium ions (Ca 2+ ), strontium ions (Sr 2+ ), zinc ions (Zn 2+ ), lithium ions (Li + ), manganese ions (Mn 2+ ), Cu 2+ , cobalt ions (Co 2+ ), cerium ions (Ce 3+ ), iron ions (Fe 3+ ), and silver ions (Ag + ). They play a vital role in different aspects of bone metabolism, such as osteoblast and osteoclast differentiation and activity, bone mineralization, and angiogenesis . Liu et al manufactured bioactive glass-ceramic (BGC) scaffolds using 3D printing and with Cu, Fe, Mn, and Co elements, which had a photothermal effect and osteogenic differentiation ability.…”
Section: Application Of Photothermal Composite Scaffolds In the Treat...mentioning
confidence: 99%
“…They play a vital role in different aspects of bone metabolism, such as osteoblast and osteoclast differentiation and activity, bone mineralization, and angiogenesis. 132 Liu et al manufactured bioactive glass-ceramic (BGC) scaffolds using 3D printing and with Cu, Fe, Mn, and Co elements, which had a photothermal effect and osteogenic differentiation ability. They conducted a study to investigate the photothermal antitumor effect and osteogenic activity of these scaffolds.…”
Section: Application Of Photothermal Composite Scaffolds In the Treat...mentioning
confidence: 99%