Metal-mediated formation of fibrillar ABri amyloid

Khan, Ayesha; Ashcroft, Alison E.; Korchazhkina, Olga; Exley, Christopher

doi:10.1016/j.jinorgbio.2004.09.004

Cited by 35 publications

(35 citation statements)

References 15 publications

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“…In concert with many other amyloidogenic peptides the measured concentrations of amylin in the blood, 1-20 pM in normal subjects rising to ca 50 pM in subjects with insulin resistance [3], appear insufficient to induce its self-aggregation in vivo and research has continued to highlight other factors which might promote the precipitation and deposition of amylin in vivo [4]. Metals have been implicated in the precipitation of amyloidogenic peptides such as Ab [5], ABri [6], NAC [7] and a-synuclein [8] and there is evidence that Zn(II) [9] and Al(III) [10] influence the aggregation of amylin. Recent evidence has suggested that the cytotoxicity of amylin might be mediated via an interaction with Cu(II) [11] which could explain some of the vulnerability of pancreatic islet b-cells to oxidative stress [12].…”

Section: Introductionmentioning

confidence: 99%

Copper(II) inhibits the formation of amylin amyloid in vitro

Ward

Walker

Exley

2008

Journal of Inorganic Biochemistry

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100

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Section: Introductionmentioning

confidence: 99%

Copper(II) inhibits the formation of amylin amyloid in vitro

Ward

Walker

Exley

2008

Journal of Inorganic Biochemistry

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100

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“…An additional suggested alternative is chelation therapy [11]. According to this therapy, suitable metal chelators may reduce metal-mediated ROS generation [11,[89][90][91][92][93][94][95]. Examples of such chelation agents are polyphenol from natural compounds such as green tea (epigallocatechin-3-gallate) and curcumin [89,96].…”

Section: Can Skin Redox Balance Be Efficiently Affected By Exogenous mentioning

confidence: 99%

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

et al. 2016

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Abstract:The skin, being the largest organ of the body, functions as a barrier between our body and the environment. It is consistently exposed to various exogenous and endogenous stressors (e.g., air pollutants, ionizing and non-ionizing irradiation, toxins, mitochondrial metabolism, enzyme activity, inflammatory process, etc.) producing reactive oxygen species (ROS) and physical damage (e.g., wounds, sunburns) also resulting in reactive oxygen species production. Although skin is equipped with an array of defense mechanisms to counteract reactive oxygen species, augmented exposure and continued reactive oxygen species might result in excessive oxidative stress leading to many skin disorders including inflammatory diseases, pigmenting disorders and some types of cutaneous malignancy. The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance and of defensive enzymes such as the phase II enzymes. Induction of the Keap1-Nrf2 pathway may have a beneficial effect in the treatment of a large number of skin disorders by stimulating an endogenous defense mechanism. However, prolonged and enhanced activation of this pathway is detrimental and, thus, limits the therapeutic potential of Keap1-Nrf2 modulators. Here, we review the consequences of oxidative stress to the skin, and the defense mechanisms that skin is equipped with. We describe the challenges of maintaining skin redox balance and its impact on skin status and function. Finally, we suggest a novel strategy for maintenance of skin redox homeostasis by modulating the Keap1-Nrf2 pathway using nanotechnology-based delivery systems.

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“…In this context it is interesting to note that high aluminium (Al) content was found in temporal cortex and hippocampus and that Al has been demonstrated to significantly alter the BBB permeability [8][9][10] with the consequence of accelerating amyloid aggregation [11]. Furthermore its in vitro co-incubation with either Zn 2+ or Cu 2+ ions was shown to promote precipitation, though possibly not amyloid fibrils formation [12].…”

Section: 1metals and Brainmentioning

confidence: 99%

“…fitted) against the available XAS data. The four models are assembled by putting together two identical A [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] ) motif blocked in space. Among the many configurations produced in this way a few of them are retained, those that appear to fulfill the required geometrical and structural constraints.…”

Section: Models Constructionmentioning

confidence: 99%

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Metals in Alzheimer’s Disease: A Combined Experimental and Numerical Approach

Rossi

2014

Advances in Alzheimer's Research

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Abstract:Alzheimer disease is a pathology causing severe problems with memory, thinking and behavior. It accounts for the majority of dementia cases and is the sixth leading cause of death in developed countries. Unfortunately a real cure is still missing and the drug treatments today available can only reduce symptoms. It belongs to a large class of diseases, called amyloidosis, in which endogenous proteins or peptides undergo a misfolding process switching from the physiological soluble configuration to a pathological fibrillar insoluble state. An important, but not yet fully elucidated, rôle appears to be played in these processes by transition metals (mainly copper and zinc) that have been observed to be present in fairly large amounts in patient's neurological plaques. In this review we will show that the challenging problem of understanding the physico-chemical basis of protein misfolding and aggregation can be successfully investigated with a combination of modern spectroscopic techniques and advanced first principle numerical simulations. In particular, it will be shown that different metals can rival in peptide binding thus adding support to the hypothesis that metal dyshomeostasis may be relevant in the Alzheimer disease development.

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Metal-mediated formation of fibrillar ABri amyloid

Cited by 35 publications

References 15 publications

Copper(II) inhibits the formation of amylin amyloid in vitro

Copper(II) inhibits the formation of amylin amyloid in vitro

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

Metals in Alzheimer’s Disease: A Combined Experimental and Numerical Approach

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