Metal-mediated synthesis of pyrrolines

Abstract

The five-membered, nitrogen-containing pyrroline ring is a privileged structure. Pyrrolines—the dihydro derivatives of pyrroles—have three structural isomer classes: 1-, 2- and 3-pyrrolines. A review on metal-mediated synthesis of the three classes of pyrrolines is given.

Advances in Base‐Mediated Post‐Ugi Transformations via Peptidyl Anion Trapping

“…Representative examples of the major classes of biologically relevant scaffolds presented in the minireview. [30][31][32][33]…”

Synthesis of Thio‐/Selenopyrrolines via SnCl4‐Catalyzed (3+2)‐Cycloadditions of Donor‐Acceptor Cyclopropanes with Thio‐/Selenocyanates

“…[1] Among the known nitrogen-containing heterocycles, pyrrolines are one of the most important classes of azaheterocycles found in a variety of natural products and bioactive molecules. [2] Furthermore, the heteroatom substituted pyrrolines have exhibited a number of interesting chemical and biological properties. [3] Literature survey has revealed that among numerous protocols to access pyrroline derivatives, [2a] (3 + 2)-cycloaddition of donor-acceptor cyclopropanes (DACs) are few.…”

Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide

“…From the marine alkaloid group with the tri-and tetrasubstituted pyrrole ring, lamellarins O, Q, R for their anticancer activity [5] and storniamids A-D for antibacterial activity [3] stand out (Figure 2). Additionally, pyrroles are useful building blocks [18][19][20][21] in the design and synthesis of naturally occurring compounds, functionalized materials, and new bioactive condensed heterocycles, and as a consequence, the interesting synthetic aspects and applications of the compounds possessing the pyrrole core have been reviewed [9][10][11][12][13]18,[22][23][24][25][26][27][28][29]. The 1,4-dihydropyridine (DHP) class is frequently the first choice of drug used in the treatment of hypertension [30] and angina [31].…”